Collective cell migration in development
Collective cell migration in development
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DOI：
10.1242/jcs.036517
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发表时间：
2009-09-15
影响因子：
4
通讯作者：
Weijer, Cornelis J.
中科院分区：
文献类型：
--
作者：
Weijer, Cornelis J.
细胞集体迁移是大多数生物体发育过程中的一个关键过程。它可以涉及紧密堆积的间充质细胞的迁移，这些细胞与频繁变化的相邻细胞进行动态接触，或者上皮片的迁移，这些上皮片通常显示更稳定的细胞-细胞相互作用和相邻细胞的不太频繁的变化。这些集体运动可以通过细胞外信号分子的短程或长程动态梯度来控制，这取决于所涉及的细胞数量和它们的迁移距离。这些梯度被一些或所有迁移细胞感知并转化为定向迁移，在许多情况下，定向迁移进一步受到细胞接触介导的吸引或排斥相互作用的调节，这些相互作用分别导致运动的接触跟随或接触抑制。对发育过程中上皮细胞群体集体迁移的研究表明，在某些情况下，只有领导细胞感知并向上迁移外部信号梯度，相邻细胞通过强烈的细胞-细胞接触跟随。在这篇评论中，我回顾了几种模式生物发育过程中不同大小的细胞群体的集体细胞迁移的研究，并讨论了我们目前对协调这种迁移的分子机制的理解。
Collective cell migration is a key process during the development of most organisms. It can involve either the migration of closely packed mesenchymal cells that make dynamic contacts with frequently changing neighbour cells, or the migration of epithelial sheets that typically display more stable cell-cell interactions and less frequent changes in neighbours. These collective movements can be controlled by short-or long-range dynamic gradients of extracellular signalling molecules, depending on the number of cells involved and their distance of migration. These gradients are sensed by some or all of the migrating cells and translated into directed migration, which in many settings is further modulated by cell-contact-mediated attractive or repulsive interactions that result in contact-following or contact-inhibition of locomotion, respectively. Studies of collective migration of groups of epithelial cells during development indicate that, in some cases, only leader cells sense and migrate up an external signal gradient, and that adjacent cells follow through strong cell-cell contacts. In this Commentary, I review studies of collective cell migration of differently sized cell populations during the development of several model organisms, and discuss our current understanding of the molecular mechanisms that coordinate this migration.