Influence of Fractionation Scheme and Tumor Location on Toxicities After Stereotactic Body Radiation Therapy for Large (≥ 5 cm) Non-Small Cell Lung Cancer: A Multi-institutional Analysis
Influence of Fractionation Scheme and Tumor Location on Toxicities After Stereotactic Body Radiation Therapy for Large (≥ 5 cm) Non-Small Cell Lung Cancer: A Multi-institutional Analysis
复制标题
立体定向体部放射治疗≥ 5cm大非小细胞肺癌分次方案和肿瘤部位对毒副反应影响的多中心分析
DOI：
10.1016/j.ijrobp.2016.11.049
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发表时间：
2017-03-15
影响因子：
7
通讯作者：
Simone, Charles B., II
中科院分区：
文献类型：
--
作者：
Verma, Vivek;Shostrom, Valerie K.;Simone, Charles B., II
目的：作为多机构分析的一部分，描述立体定向全身放射治疗(SBRT)治疗<gt；=5 cm非小细胞肺癌(NSCLC)时，分割方案和肿瘤部位对毒性的影响。2级和3级肺部毒性发生率分别为9%和4%；1名患者每天接受治疗后出现5级放射性肺炎。在整个队列中，46名患者每天接受SBRT，46名患者接受Qod(n=40)/其他非每日方案(n=6)。两组之间的临床/治疗参数相似；Qod/Other组更有可能接受3/4分数模式。与每日治疗相比，接受Qod/Other治疗的患者发生2级毒性明显减少(7%比43%，P=2肺部毒性(P=.014)。周围型肿瘤患者(n=66)比中心型肿瘤患者(n=26)更有可能接受3/4分割方案。根据肿瘤部位的不同，毒性分级没有显著差异(P>；0.05)。结论：从这项多机构研究中，SBRT对<gt；=5 cm的病变的毒性是可以接受的，日常治疗与较高的毒性发生率相关。(C)2016 Elsevier Inc.保留所有权利。
Purpose: To describe the impact of fractionation scheme and tumor location on toxicities in stereotactic body radiation therapy (SBRT) for >= 5-cm non-small cell lung cancer (NSCLC), as part of a multi-institutional analysis.Methods: Patients with primary >= 5-cm N0 M0 NSCLC who underwent = 2 and grade >= 3 toxicities, respectively. Grades 2 and 3 pulmonary toxicities occurred in 9% and 4%, respectively; 1 patient treated daily experienced grade 5 radiation pneumonitis. Of the entire cohort, 46 patients underwent daily SBRT, and 46 received QOD (n = 40)/other nondaily (n = 6) regimens. Clinical/treatment parameters were similar between groups; the QOD/other group was more likely to receive 3-/4-fraction schemas. Patients treated QOD/other experienced significantly fewer grade >= 2 toxicities as compared with daily treatment (7% vs 43%, P = 2 pulmonary toxicities (P =.014). Patients with peripheral tumors (n = 66) were more likely to receive 3-/4-fraction regimens than those with central tumors (n = 26). No significant differences in grade >= 2 toxicities were identified according to tumor location (P>.05).Conclusions: From this multi-institutional study, toxicity of SBRT for >= 5-cm lesions is acceptable, and daily treatment was associated with a higher rate of toxicities. (C) 2016 Elsevier Inc. All rights reserved.