A prospective, randomized trial of nifedipine vs. ritodrine in threatened preterm labor
A prospective, randomized trial of nifedipine vs. ritodrine in threatened preterm labor
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DOI：
10.1016/s0020-7292(98)00053-8
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发表时间：
1998-06-01
影响因子：
3.8
通讯作者：
González, AG
中科院分区：
文献类型：
--
作者：
García-Velasco, JA;González, AG
目的：比较硝苯地平与利托君治疗先兆早产的保胎效果及母体耐受性。方法：对52例孕26 ~ 34周早产的单胎妊娠进行前瞻性随机研究。延迟分娩48小时，7天，直到第36周或直到胎儿体重达到2500克的能力是评估的结果变量。多普勒超声研究进行了胎儿脐动脉作为对照。结果如下：硝苯地平组在延迟分娩方面无显著差异，但母体副作用明显减少。两组的多普勒超声结果相似。结论：硝苯地平是一种有效的和耐受性良好的宫缩抑制药物的替代品，显然不会显着改变胎儿血管血流。(C)1998年国际妇产科联合会。
Objectives: To compare the tocolytic efficacy and maternal tolerance of nifedipine with ritodrine in the management of threatened preterm labor. Methods: Prospective randomized study of 52 singleton pregnancies with preterm labor between 26 and 34 week's gestation. The capacity to delay delivery 48 h, 7 days, until week 36 or until fetal weight reached 2500 g were the outcome variables assessed. Doppler ultrasound studies were performed on the fetal umbilical artery as control. Results: No significant differences were found in the delay of delivery, but significantly fewer maternal side-effects were found in the nifedipine group. Doppler ultrasound results were similar in both groups. Conclusions: Nifedipine is a valid and well-tolerated alternative among the tocolytic drugs, and apparently does not significantly alter fetal vascular blood flow. (C) 1998 International Federation of Gynecology and Obstetrics.