The human microbiome and infectious diseases: beyond koch.
The human microbiome and infectious diseases: beyond koch.
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DOI：
10.1155/2008/296873
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发表时间：
2008
影响因子：
--
通讯作者：
Schmidt TM
中科院分区：
文献类型：
--
作者：
Young VB;Britton RA;Schmidt TM
在罗伯特·科赫（Robert Koch）将单个培养的微生物与特定疾病联系起来（科赫假设）后的世纪，人们越来越清楚地认识到，与人体相关的复杂微生物群落在健康和疾病中起着关键作用。美国国立卫生研究院最近宣布了人类微生物组项目，作为NIH医学研究路线图的一部分，其主要目标是促进我们对宿主相关微生物群落，健康和疾病之间关系的理解。然而，许多医生和研究人员对复杂微生物群落的研究和治疗操作所涉及的概念只是一知半解。我们希望提供复杂微生物群落研究中使用的概念和方法的易于访问的概述，并展示土著微生物群落的变化如何在疾病中发挥作用，如腹泻相关性腹泻和细菌性阴道病。我们还着手寻找益生菌如何用于土著微生物群的治疗操作的例子。
A century after Robert Koch linked individual cultured microbes to specific diseases (Koch’s postulates), it has become increasingly apparent that the complex community of microorganisms associated with the human body plays a key role in health and disease. The National Institutes of Health recently announced the Human Microbiome Project as part of the NIH Roadmap for medical research, with a primary goal of advancing our understanding of the relationships among host-associated microbial communities, health, and disease. Many physicians and researchers, however, have only passing familiarity with the concepts involved in the study and therapeutic manipulation of complex microbial communities.This special issue was conceived to accomplish several goals. We wanted to provide readily accessible overviews of the concepts and methods used in the study of complex microbial communities, and demonstrate how changes in indigenous microbial communities can play a role in diseases such as antibiotic-associated diarrhea and bacterial vaginosis. We also set out to find examples of how probiotics can be used for the therapeutic manipulation of the indigenous microbiota.