Pesticide appliers, biocides, and birth defects in rural Minnesota
Pesticide appliers, biocides, and birth defects in rural Minnesota
复制标题
DOI：
10.2307/3432683
复制
发表时间：
1996-04-01
影响因子：
10.4
通讯作者：
Griffith, J
中科院分区：
文献类型：
--
作者：
Garry, VF;Schreinemachers, D;Griffith, J
我们小组的早期研究表明，杀虫剂施用者的后代可能会增加出生畸形的风险。为了评估这一假设，1989年至1992年期间明尼苏达州34，772名州许可的私人农药施用者的4，935名出生与明尼苏达州出生登记处有关，该登记处在此时间范围内包含210，723名活产婴儿。出生缺陷率的所有出生异常显着增加的儿童角私人应用程序。特定的出生缺陷类别，循环/呼吸系统，泌尿生殖系统和肌肉骨骼/皮肤，表现出显着增加。对于一般人群和申请者来说，出生异常率因农作物种植地区而异。明尼苏达州西部是小麦、甜菜和土豆的主要种植区，每1000名活产婴儿的出生异常率最高：私人申请者为30.0，而同一地区的一般人口为26.9。最低的比率，23.7/1000的私人应用程序对18.3/1000的一般人口，发生在非作物地区。使用氯苯氧基除草剂和杀真菌剂的最高频率也发生在明尼苏达州西部。明尼苏达州西部一般人群的出生率显示，与申请者和中枢神经系统异常相同的三种出生异常类别的出生异常显著增加。这种增长在春季受孕的婴儿中最为明显。其他地区没有出现季节性影响。在高苯氧基除草剂/杀真菌剂使用地区，四种出生异常感兴趣类别的男性/女性性别比为2.8，而同一地区的一般人群为1.5（p = 0.05）。在最少使用地区，施用者的这一比率为2.1，而一般人群为1.7。杀虫剂使用，季节和性别比的变化，出生异常的频率过高的模式表明，在明尼苏达州西部的作物种植区的施用者和一般人群中，与杀虫剂有关的影响。
Earlier studies by our group suggested the possibility that offspring of pesticide appliers might have increased risks of birth anomalies. To evaluate this hypothesis, 4,935 births to 34,772 state-licensed, private pesticide appliers in Minnesota occurring between 1989 and 1992 were linked to the Minnesota state birth registry containing 210,723 live births in this timeframe. The birth defect rate for all birth anomalies was significantly increased in children horn to private appliers. Specific birth defect categories, circulatory/respiratory, urogenital, and musculoskeletal/integumental, showed significant increases. For the general population and for appliers, the birth anomaly rate differed by crop-growing region. Western Minnesota, a major wheat, sugar beet, and potato growing region, showed the highest rate of birth anomalies per/1000 live births: 30.0 for private appliers versus 26.9 for the general population of the same region. The lowest rates, 23.7/1000 for private appliers versus 18.3/1000 for the general population, occurred in noncrop regions. The highest frequency of use of chlorophenoxy herbicides and fungicides also occurred in western Minnesota. Births in the general population of western Minnesota showed a significant increase in birth anomalies in the same three birth anomaly categories as appliers and for central nervous system anomalies. This increase was most pronounced For infants conceived in the spring. The seasonal effect did not occur in other regions. The male/female sex ratio for the four birth anomaly categories of interest in areas of high phenoxy herbicide/fungicide use is 2.8 for appliers versus 1.5 for the general population of the same region (p = 0.05). in minimal use regions, this ratio is 2.1 for appliers versus 1.7 for the general population. The pattern of excess frequency of birth anomalies by pesticide use, season, and alteration of sex ratio suggests exposure-related effects in appliers and the general population of the crop-growing region of western Minnesota.