Risks factors for endometriosis in the rhesus monkey (Macaca mulatta): A case-control study
Risks factors for endometriosis in the rhesus monkey (Macaca mulatta): A case-control study
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DOI：
10.1093/humupd/3.2.109
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发表时间：
1997-03-01
影响因子：
13.3
通讯作者：
Kennedy, SH
中科院分区：
文献类型：
--
作者：
Hadfield, RM;Yudkin, PL;Kennedy, SH
本文分析了威斯康星州灵长类研究中心1980 ~ 1995年399只雌性恒河猴的尸检资料。自发性子宫内膜异位症被发现在81（20%）的动物。患有和不患有子宫内膜异位症的动物死亡时的平均（+/-SD）年龄分别为20.7 +/-5.5（范围10-35）岁和13.4 +/-7.7（范围4-37）岁。许多动物暴露于实验程序，包括腹腔镜、子宫切开术和雌二醇植入，并将其作为子宫内膜异位症的可能风险因素进行检查。在81只受影响的动物中，有62只与未受影响的对照组在死亡时的年龄相匹配（至1年内）及死亡年份使用条件Logistic回归确定各种因素对子宫内膜异位症发展的影响，暴露于三种或更多种雌二醇植入剂或一次或多次子宫切除术都是显著的危险因素，估计的相对风险分别为9.7（95%置信区间2.5-37.2）和5.8（95%置信区间1.6-20.2）。暴露于一次或多次腹腔镜检查的动物没有显示出发生子宫内膜异位症的风险增加。这些发现提供了深入了解妇女疾病的病因。
The autopsy records between 1980 and 1995 of 399 female rhesus monkeys (Macaca mulatta) at the Wisconsin Regional Primate Research Center were examined. Spontaneous endometriosis was found in 81 (20 %) of the animals. The mean (+/-SD) ages at death for animals with and without endometriosis were 20.7 +/-5.5 (range 10-35) and 13.4 +/- 7.7 (range 4-37) years respectively, Many of the animals had been exposed to experimental procedures, including laparoscopies, hysterotomies and oestradiol implants, and these were examined as possible risk factors for endometriosis. Of the 81 affected animals, 62 were matched to unaffected controls for age at death (to within 1 year) and year of death (to within 2 years) and the effect of various factors on the development of endometriosis was determined using conditional logistic regression, Exposure to three or more oestradiol implants or one or more hysterotomies were both significant risk factors, with estimated relative risks of 9.7 (95% confidence interval 2.5-37.2) and 5.8 (95% confidence interval 1.6-20.2) respectively. Animals that had been exposed to one or more laparoscopies showed no increased risk for developing endometriosis. These findings provide insight into the aetiology of the disease in women.