The Effect of Ivermectin in Seven Strains of Aedes aegypti (Diptera: Culicidae) Including a Genetically Diverse Laboratory Strain and Three Permethrin Resistant Strains
The Effect of Ivermectin in Seven Strains of Aedes aegypti (Diptera: Culicidae) Including a Genetically Diverse Laboratory Strain and Three Permethrin Resistant Strains
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DOI：
10.1603/me11164
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发表时间：
2012-03-01
影响因子：
2.1
通讯作者：
Foy, B. D.
中科院分区：
文献类型：
--
作者：
Deus, K. M.;Saavedra-Rodriguez, K.;Foy, B. D.
7种不同的埃及伊蚊菌株（L.），包括一种遗传多样化的实验室菌株，三种实验室选择的氯菊酯抗性菌株，一种标准参考菌株和两种最近定植的菌株，以含有不同浓度伊维菌素的人血液为食。伊维菌素降低了所有7种菌株中经伊维菌素处理的成虫的存活率、繁殖力和卵的孵化率。计算了所有菌株伊维菌素对成虫的LC50和阻止50%卵孵化的浓度。不同菌株在伊维菌素-血餐后的成虫存活率存在很大差异，所有三种氯菊酯耐药菌株对伊维菌素的敏感性都明显低于标准参考菌株。伊维菌素血餐后的孵化率各品系间差异较小，仅有1株氯菊酯抗性品系与标准对照品系差异显著。我们的研究表明，伊维菌素通过不同的机制诱导成虫死亡，降低卵的孵化率。菌株间对数转化LC50的相关分析表明，可能出现氯菊酯与伊维菌素的交叉耐药。
Seven different strains of Aedes aegypti (L.), including a genetically diverse laboratory strain, three laboratory-selected permethrin-resistant strains, a standard reference strain, and two recently colonized strains were fed on human blood containing various concentrations of ivermectin. Ivermectin reduced adult survival, fecundity, and hatch rate of eggs laid by ivermectin-treated adults in all seven strains. The LC50 of ivermectin for adults and the concentration that prevented 50% of eggs from hatching was calculated for all strains. Considerable variation in adult survival after an ivermectin-bloodmeal occurred among strains, and all three permethrin-resistant strains were significantly less susceptible to ivermectin than the standard reference strain. The hatch rate after an ivermectin bloodmeal was less variable among strains, and only one of the permethrin-resistant strains differed significantly from the standard reference strain. Our studies suggest that ivermectin induces adult mortality and decreases the hatch rate of eggs through different mechanisms. A correlation analysis of log-transformed LC50 among strains suggests that permethrin and ivermectin cross-resistance may occur.