PRESERVATION OF P300 EVENT-RELATED POTENTIAL TOPOGRAPHIC ASYMMETRIES IN SCHIZOPHRENIA WITH USE OF EITHER LINKED-EAR OR NOSE REFERENCE SITES
PRESERVATION OF P300 EVENT-RELATED POTENTIAL TOPOGRAPHIC ASYMMETRIES IN SCHIZOPHRENIA WITH USE OF EITHER LINKED-EAR OR NOSE REFERENCE SITES
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DOI：
10.1016/0013-4694(90)90083-v
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发表时间：
1990-05-01
期刊：
影响因子：
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通讯作者：
LUDWIG, A
中科院分区：
文献类型：
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作者：
FAUX, SF;SHENTON, ME;LUDWIG, A
本实验室先前的听觉P300事件相关电位（ERP）研究报告，与正常对照组相比，慢性精神分裂症患者的左侧衰减大于右侧衰减。在这些研究中，一个可能的混淆是使用了联耳参考（LER），这一直受到批评的理由是，它可能会诱导或抑制地形不对称。为了检测LER对精神分裂症P300不对称性的影响，我们记录了20名慢性药物治疗的精神分裂症患者和20名年龄匹配的正常对照组的LER和鼻参考（NR）的ERPs。我们在此报告：（1）证实了我们以前用LER和NR在28电极导联上所作的左颞部头皮区缺损的P300研究结果，这一特征在与目标刺激相关的波形中是突出的，而没有使用我们以前研究中的波形相减方法。（2）无论是精神分裂症患者还是正常人，LER和NR之间的地形图差异都没有统计学意义。和（3）由于波形变异性较低，LER在区分精神分裂症患者与正常对照组方面的性能更好。我们的结论是，LER是更可取的研究使用的主题组和方法类似于本研究。
Previous studies of the auditory P300 event-related potential (ERP) from our laboratory have reported a left- greater than right-sided attenuation in medicated chronic schizophrenics compared with normal controls. A possible confound in these studies has been the use of the linked-ear reference (LER), which has been criticized on the grounds that it might either induce or suppress topographic asymmetries. To test the effects of LER on P300 asymmetries in schizophrenia, we recorded ERPs with both LER and a nose reference (NR) in a group of 20 chronic medicated schizophrenics and in group of 20 age-matched normal controls. We here report: (1) confirmation of our previous P300 findings of left temporally scalp region deficit using both LER and NR with a 28-electrode montage; this feature was prominent in the wave form associated with the target stimulus, without the use of the wave form subtractions of our previous studies; (2) no statistically significant topographic differences between the LER and NR for either the schizophrenic or normal subjects; and (3) better performance of the LER in differentiating schizophrenics versus normal controls, due to lower wave form variability. We conclude that the LER is preferable for studies using subject groups and methodology similar to the present study.