Etiological features of borderline personality related characteristics in a birth cohort of 12-year-old children.
Etiological features of borderline personality related characteristics in a birth cohort of 12-year-old children.
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DOI：
10.1017/s0954579411000812
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发表时间：
2012-02
影响因子：
3.3
通讯作者：
Moffitt TE
中科院分区：
文献类型：
--
作者：
Belsky DW;Caspi A;Arseneault L;Bleidorn W;Fonagy P;Goodman M;Houts R;Moffitt TE
据报道，在儿童中可以观察到与边缘型人格相关的特征，这些特征与边缘型人格障碍发展的风险增加有关。目前尚不清楚儿童边缘型人格相关特征是否与成人边缘型人格障碍具有相同的病因特征。我们对1116对同性双胞胎从出生到12岁进行了纵向队列研究，调查了边缘型人格相关特征的病因。在12岁时测量的边缘性人格相关特征具有高度遗传性，在5岁时表现出较差的认知功能、冲动和更多的行为和情绪问题的儿童中更为常见，并与行为障碍、抑郁、焦虑和精神病症状共同发生。10岁之前在家庭环境中受到粗暴对待的儿童，在12岁时具有边缘性人格相关特征。这种关联显示了环境调解的证据，并且在有精神疾病家族史的儿童中更强，与边缘性病因学的素质-压力模型一致。结果表明，儿童的边缘型人格相关特征与成人的边缘型人格障碍具有共同的病因学特征，遗传和环境危险因素对边缘型人格障碍的病因学有独立和相互作用的影响。
It has been reported that borderline personality related characteristics can be observed in children, and that these characteristics are associated with increased risk for the development of borderline personality disorder. It is not clear whether borderline personality related characteristics in children share etiological features with adult borderline personality disorder. We investigated the etiology of borderline personality related characteristics in a longitudinal cohort study of 1,116 pairs of same-sex twins followed from birth through age 12 years. Borderline personality related characteristics measured at age 12 years were highly heritable, were more common in children who had exhibited poor cognitive function, impulsivity, and more behavioral and emotional problems at age 5 years, and co-occurred with symptoms of conduct disorder, depression, anxiety, and psychosis. Exposure to harsh treatment in the family environment through age 10 years predicted borderline personality related characteristics at age 12 years. This association showed evidence of environmental mediation and was stronger among children with a family history of psychiatric illness, consistent with diathesis–stress models of borderline etiology. Results indicate that borderline personality related characteristics in children share etiological features with borderline personality disorder in adults and suggest that inherited and environmental risk factors make independent and interactive contributions to borderline etiology.