Modulating Water Distribution and the Intramicellar Assembly of Sequence-Defined Ionic Peptoid Block Copolymers by the Ionic Monomer Position
Modulating Water Distribution and the Intramicellar Assembly of Sequence-Defined Ionic Peptoid Block Copolymers by the Ionic Monomer Position
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DOI：
10.1021/acs.macromol.3c00646
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发表时间：
2023-07-11
期刊：
影响因子：
5.5
通讯作者：
Zhang，Donghui
中科院分区：
文献类型：
--
作者：
Barrett，Bailee N. N.;Tung，Chi-Huan;Zhang，Donghui
通过对比度变化小角中子散射分析，确定了一系列携带单电荷单体的序列定义的离子类肽嵌段共聚物的胶束内质量异质性。我们观察到内部胶束结构，即侵入水和类肽聚合物的数量密度径向分布，受到离子单体位置的显着影响。通过将离子单体逐渐靠近亲水/疏水嵌段连接，随着链折叠和侵入水水平的增加，胶束变得不那么紧凑，以通过溶剂化来适应离子单体之间的静电排斥。这导致胶束聚集体越来越小，聚集数 (Nagg) 范围为 15.6 至 44，胶束半径 (Rb) 范围为 61 至 94 Å。这项研究强调了使用离子单体位置作为设计参数来控制纳米级胶束组件内部结构的潜力。
The intramicellar mass heterogeneity of a series of sequence-defined ionic peptoid block copolymers carrying a single charged monomer has been determined through contrast variation small-angle neutron scattering analysis. We observe that the internal micellar structure, namely, the number density radial distributions of invasive water and peptoid polymer, is significantly impacted by the location of the ionic monomer. By positioning the ionic monomer progressively closer to the hydrophilic/hydrophobic block junction, the micelles become less compact with increasing levels of chain folding and invasive water to accommodate electrostatic repulsion among the ionic monomers via solvation. This results in increasingly smaller micellar aggregates with aggregation numbers (Nagg) ranging from 15.6 to 44 and micellar radii (Rb) ranging from 61 to 94 Å. This study highlights the potential of using ionic monomer position as a design parameter to control the internal structures of nanoscale micellar assemblies.