Acute disease episodes in a Wuchereria bancrofti-endemic area of Papua New Guinea
Acute disease episodes in a Wuchereria bancrofti-endemic area of Papua New Guinea
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DOI：
10.4269/ajtmh.1999.61.319
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发表时间：
1999-08-01
影响因子：
3.3
通讯作者：
Kazura, JW
中科院分区：
文献类型：
--
作者：
Alexander, NDE;Perry, RT;Kazura, JW
在巴布亚新几内亚农村地区前瞻性监测班氏丝虫病急性发作。记录腿部、手臂、阴囊和乳房的发作频率和持续时间。观察到非常高的急性疾病发病率;仅腿部就有0.31次/人-年。发病率一般随年龄增长而增加，但乳房除外，乳房的发病集中在育龄期。男性腿部和手臂的发病率略高于女性。在所有地点，慢性疾病与急性疾病的发病率密切相关。微丝蚴血症与腿部、手臂和乳房的急性疾病有统计学显著相关性，但与阴囊无关。这项研究再次证明了淋巴丝虫病急性表现的高负担，并提供了有关危险因素的新信息，这可能会导致更好地了解病因和控制前景。
Acute disease episodes of Bancroftian filariasis were monitored prospectively in a rural area of Papua New Guinea. The frequency and duration of episodes were recorded for the leg, arm, scrotum, and breast. A very high incidence of acute disease was observed; 0.31 episodes per person-year in the leg alone. Incidence generally increased with age, except in the breast, where episodes were concentrated in the reproductive age range. Males had slightly higher incidence than females in the leg and arm. Chronic disease was strongly associated with acute disease incidence in all locations. Microfilaremia had a statistically significant association with acute disease in the leg, arm, and breast, but not the scrotum. This study again demonstrates the high burden of acute manifestations of lymphatic filariasis, and provides new information on risk factors, which may lead to better understanding of etiology and control prospects.