Arachidonic acid inhibits 5-lipoxygenase in human T cells.
Arachidonic acid inhibits 5-lipoxygenase in human T cells.
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DOI：
10.1016/0006-291x(86)90045-8
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发表时间：
1986-03
影响因子：
3.1
通讯作者：
D. Atluru;E. Lianos;J. Goodwin
中科院分区：
文献类型：
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作者：
D. Atluru;E. Lianos;J. Goodwin
关于T细胞是否产生白三烯或花生四烯酸的其他5-脂氧合酶代谢物的数据是相互矛盾的。我们报告说，外源性花生四烯酸添加到植物血凝素刺激的人类T细胞深刻抑制白三烯B4的生产，与90%的抑制作用所造成的10− 6 M花生四烯酸。12-和15-脂氧合酶途径也被花生四烯酸抑制。最近有报道称，人类T细胞不产生花生四烯酸的5-脂氧合酶代谢物，这可能是因为这些研究在孵育培养基中使用了≥ 10− 5 M的花生四烯酸。
The data on whether T cells produce leukotrienes or other 5-lipoxygenase metabolites of arachidonic acid is conflicting. We report that exogenous arachidonic acid added to phytohemagglutin-stimulated human T cells profoundly inhibits leukotriene B4 production, with 90% inhibition caused by 10−6M arachidonic acid. The 12-and 15-lipoxygenase pathways were also inhibited by arachidonic acid. Recent reports that human T cells produce no 5-lipoxygenase metabolites of arachidonic acid might be explained by the fact that the studies used ≥ 10−5M arachidonic acid in the incubation media.