Tricalcium phosphate based resorbable ceramics: Influence of NaF and CaO addition
Tricalcium phosphate based resorbable ceramics: Influence of NaF and CaO addition
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DOI：
10.1016/j.msec.2006.12.010
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发表时间：
2008-01-01
期刊：
影响因子：
--
通讯作者：
Bose, Susmita
中科院分区：
文献类型：
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作者：
Seeley, Zachary;Bandyopadhyay, Amit;Bose, Susmita
可吸收生物陶瓷由于其在体内时变的力学性能而备受关注。植入的陶瓷降解，允许骨长入，并最终用天然组织替代人工材料。基于磷酸钙的材料由于其优异的生物相容性和与天然骨的成分相似性而引起了最显著的关注。用各种金属离子掺杂这些陶瓷显著地影响它们的性能。在这项研究中，磷酸三钙（TCP）压坯通过单轴压缩与五个组成：（i）纯TCP，（ii）TCP与2.0重量%，NaF，（iii）TCP，具有3.0重量% CaO，（iv）TCP，具有2.0重量%的二元NaF和0.5重量% Ag 2 O，和（v）具有1.0重量%的季铵盐的TCP TiO 2，0.5重量% Ag 2 O，2.0重量% NaF和3.0重量%曹将这些压坯在1250 ℃下烧结4小时以获得致密的陶瓷结构。使用X射线衍射进行相分析。TCP中NaF的存在改善了致密化，并将压缩强度从70（+/-25）MPa增加到130（+/-40）MPa。CaO的加入对密度和强度没有影响。人成骨细胞的生长行为进行了研究，使用骨前体细胞系（OPC 1），以确保这些陶瓷的生物相容性没有改变，由于掺杂剂。对于长期的生物降解研究，密度，重量变化，表面微观结构，和单轴抗压强度作为时间的函数在模拟体液（SBF）进行了测量。SBF中的增重与在样品的互连孔中观察到的沉淀强烈相关。在SBF中3个月后，所有样品均显示强度降低。NaF、CaO和四元组分在模拟体液中的强度损失最稳定。(C)2007 Elsevier B. V.保留所有权利。
Resorbable bioceramics have gained much attention due to their time-varying mechanical properties in-vivo. Implanted ceramics degrade allowing bone in-growth and eventual replacement of the artificial material with natural tissue. Calcium phosphate based materials have caught the most significant attention because of their excellent biocompatibility and compositional similarities to natural bone. Doping these ceramics with various metal ions has significantly influenced their properties. In this study, tricalcium phosphate (TCP) compacts were fabricated via uniaxial compression with five compositions: (i) pure TCP, (ii) TCP with 2.0 wt.% NaF, (iii) TCP with 3.0 wt.% CaO, (iv) TCP with a binary of 2.0 wt.% NaF and 0.5 wt.% Ag2O, and (v) TCP with a quaternary of 1.0 wt.% TiO2, 0.5 wt.% Ag2O, 2.0 wt.% NaF, and 3.0 wt.% CaO. These compacts were sintered at 1250 degrees C for 4 h to obtain dense ceramic structures. Phase analyses were carried out using X-ray diffiraction. The presence of NaF in TCP improved densification and increased compression strength from 70 (+/- 25) to 130 (+/- 40) MPa. Addition of CaO had no influence on density or strength. Human osteoblast cell growth behavior was studied using an osteoprecursor cell line (OPC 1) to assure that the biocompatibility of these ceramics was not altered due to the dopants. For long-term biodegradation studies, density, weight change, surface microstructure, and uniaxial compression strength were measured as a function of time in a simulated body fluid (SBF). Weight gain in SBF correlated strongly with precipitation viewed in the inter-connected pores of the samples. After 3 months in SBF, all samples displayed a reduction in strength. NaF, CaO and the quaternary compositions maintained the most steady strength loss under SBF. (C) 2007 Elsevier B.V. All rights reserved.