Are air pollution and traffic noise independently associated with atherosclerosis: the Heinz Nixdorf Recall Study
Are air pollution and traffic noise independently associated with atherosclerosis: the Heinz Nixdorf Recall Study
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DOI：
10.1093/eurheartj/eht426
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发表时间：
2014-04-01
影响因子：
39.3
通讯作者：
Hoffmann, Barbara
中科院分区：
文献类型：
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作者：
Kaelsch, Hagen;Hennig, Frauke;Hoffmann, Barbara
生活在交通繁忙的地方与亚临床动脉粥样硬化有关，但目前尚不清楚细颗粒物（PM）空气污染或噪音这两种重要的交通相关暴露是否与这种关联有关。我们调查了长期暴露于细颗粒物和道路交通噪声与胸主动脉钙化（TAC）的独立相关性，TAC是一种可靠的亚临床动脉粥样硬化指标，我们使用了德国海因茨Nixdorf回忆研究的基线数据（2000 - 2003年），该研究是一项基于人群的队列研究，随机选择了4814名参与者。我们评估了住宅长期暴露于PM的化学运输模型，并使用噪声模型的正面水平加权24小时平均噪声（L-den）和夜间噪声（L-night）的道路交通噪声。胸主动脉钙化通过非对比增强电子束计算机断层扫描进行量化。我们使用多元线性回归来估计环境暴露与ln（TAC 1）的关联，并根据彼此、个体和邻居特征进行调整。4238名参与者（平均年龄60岁，男性49.9岁），PM2.5（空气动力学直径2.5米）和L-night都与18.1的增加的TAC负荷有关（95 CI：6.6; 30.9）和3.9（95 CI 0.0; 8.0）。我们没有观察到效果措施修改的PM2.5协会L-night或反之亦然。长期暴露于细PM和夜间交通噪音都独立与亚临床动脉粥样硬化，并可能都有助于关联的交通接近动脉粥样硬化。
Living close to high traffic has been linked to subclinical atherosclerosis, however it is not clear, whether fine particulate matter (PM) air pollution or noise, two important traffic-related exposures, are responsible for the association. We investigate the independent associations of long-term exposure to fine PM and road traffic noise with thoracic aortic calcification (TAC), a reliable measure of subclinical atherosclerosis.We used baseline data (20002003) from the German Heinz Nixdorf Recall Study, a population-based cohort of 4814 randomly selected participants. We assessed residential long-term exposure to PM with a chemistry transport model, and to road traffic noise using faade levels from noise models as weighted 24 h mean noise (L-den) and night-time noise (L-night). Thoracic aortic calcification was quantified from non-contrast enhanced electron beam computed tomography. We used multiple linear regression to estimate associations of environmental exposures with ln(TAC1), adjusting for each other, individual, and neighbourhood characteristics. In 4238 participants (mean age 60 years, 49.9 male), PM2.5 (aerodynamic diameter 2.5 m) and L-night are both associated with an increasing TAC-burden of 18.1 (95 CI: 6.6; 30.9) per 2.4 g/m(3) PM2.5 and 3.9 (95 CI 0.0; 8.0) per 5dB(A) L-night, respectively, in the full model and after mutual adjustment. We did not observe effect measure modification of the PM2.5 association by L-night or vice versa.Long-term exposure to fine PM and night-time traffic noise are both independently associated with subclinical atherosclerosis and may both contribute to the association of traffic proximity with atherosclerosis.