HE4 and epithelial ovarian cancer: Comparison and clinical evaluation of two immunoassays and a combination algorithm
HE4 and epithelial ovarian cancer: Comparison and clinical evaluation of two immunoassays and a combination algorithm
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DOI：
10.1016/j.cca.2011.04.028
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发表时间：
2011-07-15
影响因子：
5
通讯作者：
Pecorelli, Sergio
中科院分区：
文献类型：
--
作者：
Ruggeri, Giuseppina;Bandiera, Elisabetta;Pecorelli, Sergio
Background: Two commercial immunoassays for HE4 have been compared and the diagnostic accuracy of HE4, CA 125 and the combinatory ROMA algorithm for epithelial ovarian cancer (EOC) has been evaluated.Methods: HE4 and CA125 were measured on sera obtained from 259 women (73 healthy, 90 with benign ovarian or adnexal diseases, 96 with EOC). The ARCHITECT CMIA HE4 assay was compared with the Fujirebio EIA HE4, and the risk for EOC by the combinatory ROMA algorithm (HE4 + CA 125) was assessed with both HE4 assays.Results: The CMIA HE4 assay showed a good linearity (r > 0.9998) and precision (interassay and total CVs
