An Overview of Sarcopenic Obesity
An Overview of Sarcopenic Obesity
复制标题
DOI：
10.1016/j.jocd.2015.04.013
复制
发表时间：
2015-10-01
影响因子：
2.5
通讯作者：
Cauley, Jane A.
中科院分区：
文献类型：
--
作者：
Cauley, Jane A.
肌肉萎缩性肥胖症（Sarkenic obesity，SO）是指肌肉减少症与肥胖症并存的疾病。在这种情况下，瘦体重与脂肪量之间存在不成比例。对SO的研究很重要，因为肌肉减少症和肥胖症的存在可能会对健康产生重要影响。然而，SO的研究一直受到不同数量的SO定义的阻碍。肌肉减少症的各种定义包括四肢质量与身高（2）或体重的比值，肌肉力量或身体功能的测量。最近的定义包含了所有三个。肥胖通常由高体重指数定义，但一些研究依赖于身体脂肪或内脏脂肪的百分比。根据定义，SO在老年人群中的患病率范围为0%至41%。随着年龄的增长，瘦体重的减少和脂肪量的增加可能有共同的病因学途径。体力活动的减少会导致肌肉力量差，肌肉质量降低和脂肪浸润增加;所有这些都可能导致脂肪量增加。脂肪量的增加以及伴随的脂肪因子和炎症的增加可能进一步不利地影响肌肉质量。除了肌肉减少症或单纯肥胖外，SO还与行动能力障碍的风险增加有关。需要更多的研究来进一步了解SO的病理生理学及其后果。旨在减少SO的干预措施可以改善身体功能，减少残疾和死亡。
Sarcopenic obesity (SO) refers to the copresence of sarcopenia and obesity. In this condition, a disproportion exists between the amount of lean mass relative to fat mass. Research on SO is important because the presence of both sarcopenia and obesity may have important health consequences. However, SO research has been hampered by the disparate number of definitions of SO. Various definitions of sarcopenia include ratios of appendicular mass to height(2) or body weight, measures of muscle strength, or physical function. More recent definitions incorporate all 3. Obesity is usually defined by high body mass index, but some studies have relied on percent body fat or visceral fat. Depending on the definition, the prevalence of SO ranges from 0% to 41% in older populations. The loss of lean mass and increase in fat mass with advancing age may share common etiologic pathways. Declines in physical activity can lead to poor muscle strength, lower muscle mass, and increased fat infiltration; all of which could lead to increases in fat mass. The increases in fat mass and accompanying increases in adipokines and inflammation may further adversely affect muscle quality. SO has been related to an increased risk of mobility disability, above and beyond sarcopenia, or obesity alone. Additional research is needed to further our understanding of the pathophysiology of SO and its consequences. Interventions aimed at reducing SO may improve physical function as well as reduce disability and death.