Naming and recognizing famous faces in temporal lobe epilepsy
Naming and recognizing famous faces in temporal lobe epilepsy
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DOI：
10.1212/01.wnl.0000073621.18013.e1
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发表时间：
2003-07-08
期刊：
影响因子：
9.9
通讯作者：
Chiaravalloti, ND
中科院分区：
文献类型：
--
作者：
Glosser, G;Salvucci, AE;Chiaravalloti, ND
目的：评价癫痫患者前颞叶切除术(ATL)前后熟悉名人的命名和面孔再认情况。方法：对63例颞叶癫痫(TLE)患者ATL治疗前、后及10例年龄、文化程度相匹配的健康对照组进行命名和描述。结果：拍照名人的自发命名在所有患者组中均有损害，但在接受左侧ATL的患者中最为异常。当被允许通过口头描述而不是命名来展示对著名面孔的认识时，左侧TLE、左侧ATL和右侧TLE患者的水平改善到正常水平，但右侧ATL患者仍然受损，这表明在识别著名面孔方面存在新的缺陷。名人的命名与其他常见事物的命名、言语记忆和对面孔的知觉辨别有关。对名人照片的身份再认更多地与视觉空间知觉和记忆有关。结论：右侧颞叶前部区域的病变损害了熟悉面孔的身份识别和新面孔的学习。左侧颞叶的病变，特别是前部区域，会干扰对已知人物姓名的获取，但不会影响对名人身份的识别。结果与偏侧的前颞叶结构在面部识别和命名独特实体中的假设作用是一致的。
Objective: To assess naming and recognition of faces of familiar famous people in patients with epilepsy before and after anterior temporal lobectomy (ATL). Methods: Color photographs of famous people were presented for naming and description to 63 patients with temporal lobe epilepsy (TLE) either before or after ATL and to 10 healthy age- and education-matched controls. Results: Spontaneous naming of photographed famous people was impaired in all patient groups, but was most abnormal in patients who had undergone left ATL. When allowed to demonstrate knowledge of the famous faces through verbal descriptions, rather than naming, patients with left TLE, left ATL, and right TLE improved to normal levels, but patients with right ATL were still impaired, suggesting a new deficit in identifying famous faces. Naming of famous people was related to naming of other common objects, verbal memory, and perceptual discrimination of faces. Recognition of the identity of pictured famous people was more related to visuospatial perception and memory. Conclusions: Lesions in anterior regions of the right temporal lobe impair recognition of the identities of familiar faces, as well as the learning of new faces. Lesions in the left temporal lobe, especially in anterior regions, disrupt access to the names of known people, but do not affect recognition of the identities of famous faces. Results are consistent with the hypothesized role of lateralized anterior temporal lobe structures in facial recognition and naming of unique entities.