Signals from posterior parietal area 5 to motor cortex during locomotion
Signals from posterior parietal area 5 to motor cortex during locomotion
复制标题
DOI：
10.1093/cercor/bhac118
复制
发表时间：
2022-04-05
期刊：
影响因子：
3.7
通讯作者：
Marlinski，Vladimir
中科院分区：
文献类型：
--
作者：
Beloozerova，Irina N.;Nilaweera，Wijitha U.;Marlinski，Vladimir
顶叶皮层的第5区是“背流”皮层通路的一部分，它处理视觉信息以进行动作。5区最终传递给运动皮层的信号是未知的，运动皮层是向脊髓提供输出的主要区域。我们分析了5区的神经元活动在视觉独立的运动在一个平面上和视觉依赖的运动在一个水平的梯子上的猫专注于皮质神经元（CC）投射到运动皮层从上层和深层的皮质层，并将其与相邻的身份不明的神经元（noID）。我们发现，从视觉独立的运动过渡到视觉依赖的运动，低放电的CC在第V层加倍和细胞的比例与2爆发每步趋于增加。在第V层中，这组2次爆发出现了2个活动峰值，与之前描述的视线沿着远离动物的表面转移的峰值相一致。一个突发和任何亚群在颗粒层没有传输任何明确的统一的步幅相关的信号到运动皮层。大多数CC组的活动并不反映他们的noID同行。在肩、肘或腕/爪上具有感受野的CC与运动皮质的锥体束神经元（皮质脊髓细胞）的相应组以相反的相位放电。
Area 5 of the parietal cortex is part of the “dorsal stream” cortical pathway which processes visual information for action. The signals that area 5 ultimately conveys to motor cortex, the main area providing output to the spinal cord, are unknown. We analyzed area 5 neuronal activity during vision-independent locomotion on a flat surface and vision-dependent locomotion on a horizontal ladder in cats focusing on corticocortical neurons (CCs) projecting to motor cortex from the upper and deeper cortical layers and compared it to that of neighboring unidentified neurons (noIDs). We found that upon transition from vision-independent to vision-dependent locomotion, the low discharge of CCs in layer V doubled and the proportion of cells with 2 bursts per stride tended to increase. In layer V, the group of 2-bursters developed 2 activity peaks that coincided with peaks of gaze shifts along the surface away from the animal, described previously. One-bursters and either subpopulation in supragranular layers did not transmit any clear unified stride-related signal to the motor cortex. Most CC group activities did not mirror those of their noID counterparts. CCs with receptive fields on the shoulder, elbow, or wrist/paw discharged in opposite phases with the respective groups of pyramidal tract neurons of motor cortex, the cortico-spinal cells.