Hematologic and clinical indices of malaria in a semi-immune population of western Thailand
Hematologic and clinical indices of malaria in a semi-immune population of western Thailand
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DOI：
10.4269/ajtmh.2004.70.8
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发表时间：
2004-01-01
影响因子：
3.3
通讯作者：
Wongsrichanalai, C
中科院分区：
文献类型：
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作者：
Erhart, LM;Yingyuen, K;Wongsrichanalai, C
本研究检查了在泰国与缅甸西部边境的Maesod的急性恶性疟原虫或间日疟原虫感染者的血液学特征，并与也向疟疾诊所报告的发热、非寄生虫血症者进行了比较。979例受试者为疟疾阴性，414例感染恶性疟原虫，646例感染间日疟原虫。寄生虫血症患者的白色血细胞、红细胞、血小板和血红蛋白水平明显低于疟疾阴性者。首次发现血小板减少症伴寄生虫血症的平行趋势与恶性疟原虫和间日疟原虫感染相关。使用逻辑回归分析，血小板计数<150，000/穆尔的人患疟疾的可能性是血小板计数大于或等于150，000/穆尔的人的12-15倍。这项研究补充了以前关于疟疾血液学影响的文献，并有助于确定半免疫人群的这些变化。血小板减少症被确定为这些发热患者中疟疾的关键指标。
This study examines hematologic profiles of persons with acute Plasmodium falciparum or P. vivax infection in Maesod on Thailand's western border with Myanmar compared with febrile, non-parasitemic persons also reporting to malaria clinics. Nine hundred seventy-nine subjects were malaria-negative, 414 were infected with P. falciparum, and 646 were infected with P. vivax. Persons with patent parasitemia tended to have significantly lower white blood cell, red blood cell, platelet, and hemoglobin levels than those who were malaria-negative. For the first time, a parallel trend in thrombocytopenia with parasitemia was found to be associated with both P. falciparum, and P. vivax infection. Using logistic regression, persons with platelet counts < 150,000/muL were 12-15 times more likely to have malaria than persons with platelet counts greater than or equal to 150,000/muL. This study supplements previous literature on the hematologic effects of malaria and helps define those alterations for a semi-immune population. Thrombocytopenia is identified as a key indicator of malaria in these febrile patients.