Association of the androgen receptor gene (AR) with ADHD and conduct disorder.
Association of the androgen receptor gene (AR) with ADHD and conduct disorder.
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DOI：
10.1097/00001756-199905140-00036
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发表时间：
1999-05
期刊：
影响因子：
1.7
通讯作者：
D. Comings;Cynthia Chen;Shijuan Wu;D. Muhleman
中科院分区：
文献类型：
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作者：
D. Comings;Cynthia Chen;Shijuan Wu;D. Muhleman
外化行为的男性优势表明，X-连锁雄激素基因可能参与。由于AR基因CAG和GGC多态性的较短等位基因与基因表达增加相关，我们试图确定它们是否也与外化行为相关。我们检查了302例由抽动秽语综合征先证者和对照者组成的受试者。方差分析显示，AR单倍型与ADHD（p < 0.0001）、品行障碍（CD; p < 0.017）和对立违抗性障碍（ODD; p < 0.004）之间存在显著关联，在两种多态性中具有较长等位基因的人得分最低。这些结果表明，人类AR基因的遗传变异在人类外化障碍中起作用。
The male predominance of externalizing behaviors suggests that the X-linked androgen gene might be involved. Since the shorter alleles of the CAG and GGC polymorphisms of the AR gene are associated with increased gene expression we sought to determine whether they were also associated with externalizing behaviors. We examined 302 subjects consisting of Tourette syndrome probands and controls. ANOVA showed a significant association between the AR haplotypes and ADHD (p < 0.0001), conduct disorder (CD; p < 0.017), and oppositional defiant disorder (ODD; p < 0.004) with the lowest scores in those with the longer alleles at both polymorphisms. These results suggest that genetic variation at the human AR gene plays a role in human externalizing disorders.