ON-OFF THERMOCONTROL OF SOLUTE TRANSPORT .2. SOLUTE RELEASE FROM THERMOSENSITIVE HYDROGELS
ON-OFF THERMOCONTROL OF SOLUTE TRANSPORT .2. SOLUTE RELEASE FROM THERMOSENSITIVE HYDROGELS
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DOI：
10.1023/a:1015860824953
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发表时间：
1991-05-01
影响因子：
3.7
通讯作者：
KIM, SW
中科院分区：
文献类型：
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作者：
BAE, YH;OKANO, T;KIM, SW
合成了聚N-异丙基丙烯酰胺（NIPAAm）/聚四亚甲基醚二醇（PTMEG）互穿聚合物网络（IPN），并研究了其作为温敏性水凝胶用于药物释放的可行性。 纳入这些矩阵的吲哚美辛的释放表现出脉动的模式，在响应温度的变化，是敏感的温度波动几度。 引发开关释放的温度偏离了未加载凝胶的凝胶崩溃温度，可能是因为溶质对网络性质的影响。 吲哚美辛在每个温度循环的低温区（过程中）的滞后时间和释放曲线受凝胶组成和应用温度的影响。 这项研究的结果表明，溶质的释放可以调节的快速去溶胀的凝胶表面响应于温度。
Poly(N-isopropylacrylamide) (NIPAAm)/polytetramethylene ether glycol (PTMEG) interpenetrating polymer networks (IPNs) were synthesized and their feasibility as thermosensitive hydrogels for drug release was investigated. The release of indomethacin incorporated into these matrices showed pulsatile patterns in response to temperature changes and was sensitive to a few degrees of temperature fluctuation. The temperature inducing on-off release deviated from the gel collapse temperature of unloaded gel, possibly because of solute effects on network properties. The lag time and release profile of indomethacin in the low-temperature region (on process) of each temperature cycle were affected by the gel composition and applied temperature. The results of this study demonstrate that solute release can be regulated by rapid deswelling of the surface of the gels in response to temperature.