Phosphine Sequentially Catalyzed Domino 1,6-Addition/Annulation: Access to Functionalized Chromans and Tetrahydroquinolines with an Ethynyl-Substituted All-Carbon Quaternary Center
Phosphine Sequentially Catalyzed Domino 1,6-Addition/Annulation: Access to Functionalized Chromans and Tetrahydroquinolines with an Ethynyl-Substituted All-Carbon Quaternary Center
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膦顺序催化多米诺 1,6-加成/成环：通过乙炔基取代的全碳四元中心获得功能化色满和四氢喹啉
DOI：
10.1021/acs.orglett.8b03819
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发表时间：
2019
期刊：
影响因子：
5.2
通讯作者：
Huang You
中科院分区：
文献类型：
--
作者：
Zhu Yannan;Wang Dan;Huang You
使用对醌甲基化物 (p-QM) 和 α-取代联烯酸酯开发了一种新型膦顺序催化多米诺骨牌 1, 6-加成/成环过程，该过程生成一系列含有乙炔基取代的全碳四元中心的苯并二氢吡喃和四氢喹啉衍生物，产率高达 97%，dr 为 20:1。价值。在此反应中，联烯酸充当 C2 合成子。
A novel phosphine sequentially catalyzed domino 1, 6-addition/annulation process has been developed usingp-quinone methides (p-QMs) and α-substituted allenoates which generates a series of chroman and tetrahydroquinoline derivatives containing an ethynyl-substituted all-carbon quaternary center with up to 97% yield and 20:1 dr. value. In this reaction, allenoates act as C2 synthons.