Serotonin 1A agonist and cardiopulmonary improvements with whole-body exercise in acute, high-level spinal cord injury: a retrospective analysis.
Serotonin 1A agonist and cardiopulmonary improvements with whole-body exercise in acute, high-level spinal cord injury: a retrospective analysis.
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DOI：
10.1007/s00421-020-04536-w
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发表时间：
2021-03
影响因子：
3
通讯作者：
Taylor JA
中科院分区：
文献类型：
--
作者：
Vivodtzev I;Picard G;O'Connor K;Taylor JA
高位脊髓损伤（SCI）可导致脊髓及脊髓以上水平的呼吸控制功能缺陷，致使机体对运动及训练相关适应性变化的通气反应不足。我们假设，一种已知能在动物模型中改善呼吸功能的血清素激动剂，能够提高急性高位脊髓损伤患者对全身功能性电刺激（FES）运动训练的适应性。
我们在研究项目中确定了10名患者（受伤时间<2年，脊髓损伤节段在C4 - T3），他们在2012年至2018年间服用丁螺环酮（29 ± 17毫克/天）的同时，进行了6个月的FES划船训练。我们还确定了11名匹配良好的个体，他们同样进行了6个月的训练，但未服用丁螺环酮。训练前后分别进行了递增负荷FES划船运动峰值测试和静息肺功能测试。
与对照组相比，服用丁螺环酮的患者在峰值摄氧量（VO₂peak：+0.24 ± 0.23 升/分钟 对比 +0.10 ± 0.13 升/分钟，p = 0.08）和峰值通气量（VEpeak：+6.5 ± 8.1 升/分钟 对比 -0.7 ± 6.9 升/分钟，p < 0.05）方面有更大幅度的提升。此外，所有患者的VO₂peak和VEpeak变化呈相关性（r = 0.63，p < 0.01），而在服用丁螺环酮的患者中这种相关性最强（r = 0.85，p < 0.01）。再者，丁螺环酮组呼吸功能的变化与峰值潮气量的增加相关（r > 0.66，p < 0.05）。
这些结果表明，丁螺环酮可改善急性高位脊髓损伤患者对FES运动训练的心肺适应性。通气能力和有氧能力提升之间的强相关性表明，呼吸功能的改善是一种作用机制，然而，还需要对照研究来确定这一初步发现是否具有可重复性。
High-level spinal cord injury (SCI) can result in spinal and supraspinal respiratory control deficits leading to insufficient ventilatory responses to exercise and training-related adaptations. We hypothesized a serotonin agonist, known to improve respiratory function in animal models, would improve adaptations to whole-body functional electrical stimulation (FES) exercise training in patients with acute high-level SCI. We identified ten patients (<2 years of injury with SCI from C4-T3) in our program who had performed six months of FES-row training while on Buspirone (29 ± 17 mg/day) between 2012 and 2018. We also identified well-matched individuals who trained for six months but not on Buspirone (n = 11). A peak incremental FES-rowing exercise test and resting pulmonary function test had been performed before and after training. Those on Buspirone demonstrated greater increases in peak oxygen consumption (VO2peak: +0.24 ± 0.23 vs. +0.10 ± 0.13 L/min, p=0.08) and peak ventilation (VEpeak: +6.5 ± 8.1 vs. −0.7 ± 6.9 L/min, p<0.05) compared to control. In addition, changes in VO2peak and VEpeak were correlated across all patients (r=0.63, p<0.01), but most strongly in those on Buspirone (r=0.85, p<0.01). Furthermore, changes in respiratory function correlated to increased peak tidal volume in the Buspirone group (r>0.66, p<0.05). These results suggest Buspirone improves cardiorespiratory adaptations to FES-exercise training in individuals with acute, high-level SCI. The strong association between increases in ventilatory and aerobic capacities suggests improved respiratory function is a mechanism, however controlled studies are needed to determine if this preliminary finding is reproducible.
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DOI：
10.3928/02793695-20151022-01
发表时间：
2015-11-01
影响因子：
1.2
作者：
Howland, Robert H.
通讯作者：
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影响因子：
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作者：
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DOI：
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发表时间：
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期刊：
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DOI：
10.1164/ajrccm.152.3.7663792
发表时间：
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DOI：
10.1249/mss.0000000000000880
发表时间：
2016-06-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
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作者：
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