MYOCARDIAL BLOOD-FLOW AT REST AND DURING PHARMACOLOGICAL VASODILATION IN CARDIAC TRANSPLANTS DURING AND AFTER SUCCESSFUL TREATMENT OF REJECTION
MYOCARDIAL BLOOD-FLOW AT REST AND DURING PHARMACOLOGICAL VASODILATION IN CARDIAC TRANSPLANTS DURING AND AFTER SUCCESSFUL TREATMENT OF REJECTION
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DOI：
10.1161/01.cir.90.1.204
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发表时间：
1994-07-01
期刊：
影响因子：
37.8
通讯作者：
SCHELBERT, HR
中科院分区：
文献类型：
--
作者：
CHAN, SY;KOBASHIGAWA, J;SCHELBERT, HR
研究背景：在急性移植排斥反应中，冠状动脉内相对血流储备减少，但在静息和充血时，排斥反应对绝对血流的影响尚未确定。这已经成为可能，通过非侵入性定量心肌血流量与positron emission tomography.Methods和结果心肌血流量（MBF）在休息和潘生丁诱导充血期间进行了量化，在10个移植患者（A组）在急性，活检证实的排斥事件，并再次成功的免疫抑制治疗后，在6个移植患者（组B）没有以前的排斥事件。在A组患者中，排斥反应期间静息时MBF平均为1.7+/-0.3 mL.min（-1）.g（-1），充血时为2.5+/-0.9 mL.min（-1）.g（-1）;恢复后，静息时MBF下降至1.2+/-0.3 mL。（-1）.g（-1）（P
Background The relative intracoronary flow reserve has been found to be reduced during acute transplant rejection, but the effects of rejection on absolute flows at rest and during hyperemia have not been established previously. This has now become possible through noninvasive quantification of myocardial blood flow with positron emission tomography.Methods and Results Myocardial blood flow (MBF) at rest and during dipyridamole-induced hyperemia was quantified in 10 transplant patients (group A) during an acute, biopsy-proven rejection episode and again after successful immunosuppressive treatment and in 6 transplant patients (group B) without prior rejection episodes. In group A patients, MBF during rejection averaged 1.7+/-0.3 mL.min(-1).g(-1) at rest and 2.5+/-0.9 mL.min(-1).g(-1) during hyperemia; after recovery, MBF at rest had declined to 1.2+/-0.3 mL.(-1).g(-1) (P