Antimicrobial activity and surface properties of an acrylic resin containing a biocide polymer
Antimicrobial activity and surface properties of an acrylic resin containing a biocide polymer
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DOI：
10.1111/ger.12031
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发表时间：
2014-09-01
期刊：
影响因子：
2
通讯作者：
Rodriguez, Larissa S.
中科院分区：
文献类型：
--
作者：
Compagnoni, Marco A.;Pero, Ana C.;Rodriguez, Larissa S.
目的：评估含有杀菌剂聚合物聚（2-叔丁基氨基乙基）甲基丙烯酸酯 (PTBAEMA) 的丙烯酸树脂的抗菌活性和表面性能。背景：已经提出了几种预防口腔感染的方法，包括在丙烯酸树脂中加入抗菌剂。材料和方法：丙烯酸树脂 (Lucitone 550) 样品分为两组：0%（对照）和 10% PTBAEMA。通过对其中一种微生物金黄色葡萄球菌、变形链球菌和白色念珠菌的粘附测定来评估抗菌活性。通过原子力显微镜和通过接触角测量确定的润湿性特性来表征表面形貌。 结果：金黄色葡萄球菌（对照：7.9 +/- 0.8；10%：3.8 +/- 3.3）和变形链球菌（对照：7.5 +/- 0.7；10%：5.1 +/- 2.7）的活细胞数据（log (CFU + 1)/ml）显示显着下降10% PTBAEMA（曼-惠特尼，p < 0.05）。对于白色念珠菌（对照：6.6 +/- 0.2；10%：6.6 +/- 0.4），对照和 10% PTBAEMA 之间没有显着差异（Kruskal-Wallis，p > 0.05）。掺入10%PTBAEMA提高了丙烯酸树脂表面粗糙度，降低了接触角。结论：丙烯酸树脂中掺入10%PTBAEMA提高了丙烯酸树脂表面的润湿性和粗糙度；并降低变形链球菌和金黄色葡萄球菌在亚克力表面的粘附力，但对白色念珠菌没有表现出抗菌作用。
Objective: To evaluate the antimicrobial activity and surface properties of an acrylic resin containing the biocide polymer poly (2-tert-butylaminoethyl) methacrylate (PTBAEMA).Background: Several approaches have been proposed to prevent oral infections, including the incorporation of antimicrobial agents to acrylic resins.Materials and methods: Specimens of an acrylic resin (Lucitone 550) were divided into two groups: 0% (control) and 10% PTBAEMA. Antimicrobial activity was assessed by adherence assay of one of the microorganisms, Staphylococcus aureus, Streptococcus mutans and Candida albicans. Surface topography was characterised by atomic force microscopy and wettability properties determined by contact angle measurements.Results: Data of viable cells (log (CFU + 1)/ml) for S. aureus (control: 7.9 +/- 0.8; 10%: 3.8 +/- 3.3) and S. mutans (control: 7.5 +/- 0.7; 10%: 5.1 +/- 2.7) showed a significant decrease with 10% of PTBAEMA (Mann-Whitney, p < 0.05). For C. albicans (control: 6.6 +/- 0.2; 10%: 6.6 +/- 0.4), there was no significant difference between control and 10% of PTBAEMA (Kruskal-Wallis, p > 0.05). Incorporating 10% PTBAEMA increased surface roughness and decreased contact angles.Conclusion: Incorporating 10% PTBAEMA into acrylic resins increases wettability and roughness of acrylic resin surface; and decreases the adhesion of S. mutans and S. aureus on acrylic surface, but did not exhibit antimicrobial effect against C. albicans.