Impact of the pneumococcal conjugate vaccines on invasive pneumococcal disease in France, 2001-2012
Impact of the pneumococcal conjugate vaccines on invasive pneumococcal disease in France, 2001-2012
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DOI：
10.1016/j.vaccine.2014.11.011
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发表时间：
2015-01-03
期刊：
影响因子：
5.5
通讯作者：
Levy-Bruh, D.
中科院分区：
文献类型：
--
作者：
Lepoutre, A.;Varon, E.;Levy-Bruh, D.
背景和目的：2003年法国推荐15岁儿童接种7价肺炎球菌结合疫苗（PCV7）。方法：利用epepbac实验室网络2001 - 2012年报告病例，计算IPD发生率。在国家肺炎球菌参考中心对侵袭性分离株的血清型分布进行了评估。比较了PCV7前（2001-2002年）、PCV7晚期（2008-2009年）和PCV13后（2012年）期间IPD发病率。结果：pcv覆盖率从2004年出生队列的56%增加到2008年及以后出生队列的94%。在引入PCV7后，2001-2002年和2008-2009年期间儿童IPD发病率下降了19%
Context and aims: Vaccination with the 7-valent pneumococcal conjugate vaccine (PCV7) was recommended in France in 2003 for children 15 years).Methods: IPD rates were calculated using cases reported from 2001 to 2012 to Epibac, a laboratory network. The distribution of serotypes was assessed from invasive isolates serotyped at the National reference Centre for Pneumococci. IPD incidence rates were compared between the pre-PCV7 (2001-2002), late PCV7 (2008-2009) and post PCV13 (2012) periods.Results: The PCVs coverage increased from 56% in the 2004 birth-cohort to 94% in the 2008 and following birth-cohorts. Following PCV7 introduction, IPD incidence decreased by 19% between 2001-2002 and 2008-2009 in children