Taxus spp. needles contain amounts of taxol comparable to the bark of Taxus brevifolia: analysis and isolation.
Taxus spp. needles contain amounts of taxol comparable to the bark of Taxus brevifolia: analysis and isolation.
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红豆杉属
DOI：
10.1021/np50071a017
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发表时间：
1990
影响因子：
5.1
通讯作者：
Cragg,GM
中科院分区：
文献类型：
--
作者：
Witherup,KM;Look,SA;Stasko,MW;Ghiorzi,TJ;Muschik,GM;Cragg,GM
随着对这种有前途的癌症化疗剂的需求增加，需要抗肿瘤天然产物紫杉醇[1]的新来源。目前，临床研究中紫杉醇的来源主要是短叶红豆杉（Taxus brevifolia）的树皮，这是一种潜在的有限来源。利用分析方法，对6种红豆杉属植物的针叶和茎中的紫杉醇[1]和10-脱乙酰基浆果赤霉素III [5]进行了检测，后者是一种可通过半合成途径转化为紫杉醇的相关化合物。紫杉醇的含量与报道的T.短叶红豆杉的针叶中发现的四个物种的调查。此外，还从一种紫杉属植物的针叶中分离出紫杉醇。因此，红豆杉针叶可能提供这种有价值的化合物的可再生来源。
New sources for the antitumor natural product taxol [1] are needed as demands for this promising cancer chemotherapeutic agent increase. Presently, supplies of taxol for clinical studies are obtained from the bark of Taxus brevifolia, a potentially limited source.Using analytical methods, the needles and stems of six Taxus species have been examined for taxol [1] and 10-deacetylbaccatin III [5], a related compound that can be converted to taxol through a semi-synthetic route. Amounts of taxol comparable to quantities reported from the bark of T. brevifolia were found in the needles of four of the Taxus species investigated. In addi-tion, taxol was isolated from the needles of one Taxus species. Thus, Taxusneedles mayprovide a renewable source of this valuable compound.