Testing a dual-modality system that combines full-field digital mammography and automated breast ultrasound.
Testing a dual-modality system that combines full-field digital mammography and automated breast ultrasound.
复制标题
测试结合全场数字乳房X线摄影和自动乳房超声的双模式系统。
DOI：
10.1016/j.clinimag.2015.11.024
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发表时间：
2016-05
期刊：
影响因子：
2.1
通讯作者：
Wilson HS
中科院分区：
文献类型：
--
作者：
Vaughan CL;Douglas TS;Said-Hartley Q;Baasch RV;Boonzaier JA;Goemans BC;Harverson J;Mingay MW;Omar S;Smith RV;Venter NC;Wilson HS
这项研究的目的是测试一种新型的双模式成像系统，该系统在单一平台上结合了全场数字乳房X光摄影(FFDM)和自动乳房超声(ABUS)。我们的Aceso系统以希腊治愈女神的名字命名，专门为乳房组织致密的女性早期发现癌症而设计。Aceso首先使用两个行业标准进行测试：使用EUREF认可的CDMAM体模评估FFDM图像；使用CIRS 040GSE超声体模评估ABUS图像的质量。此外，58名女性参加了一项临床试验：51名年龄在40岁至65岁之间的健康志愿者，7名由乳腺诊所转介的患者，其中6名患者经活检证实患有乳腺癌。CDMAM测试表明，FFDM的结果是“可接受的”，但没有达到“可实现”的程度，这归因于使用的低剂量。ABUS图像具有良好的深度穿透性(80 Mm)和足够的轴向分辨率(0.5 mm)，但2 mm的横向分辨率被认为太粗。在一名乳腺组织极其致密的42岁志愿者身上，ABUS检查发现了一种病变(良性囊性病变)，在FFDM图像中，该病变在X光检查中是隐蔽的。对于一位73岁的乳房肥胖症患者，成功地发现了恶性病变，并在FFDM和ABUS图像中进行了联合注册。平均而言，每个女性在采集室停留的时间不到11分钟。虽然FFDM和ABUS图像的质量都有改进的空间，但Aceso已经证明了它有能力为一系列具有不同乳房密度的女性获取具有临床意义的图像，因此具有作为筛查设备的潜力。
The aim of this study was to test a novel dual-modality imaging system that combines full-field digital mammography (FFDM) and automated breast ultrasound (ABUS) in a single platform. Our Aceso system, named after the Greek goddess of healing, was specifically designed for the early detection of cancer in women with dense breast tissue. Aceso was first tested using two industry standards: a CDMAM phantom as endorsed by EUREF was used to assess the FFDM images; and the CIRS 040GSE ultrasound phantom was imaged to evaluate the quality of the ABUS images. In addition, 58 women participated in a clinical trial: 51 were healthy volunteers aged between 40 and 65, while 7 were patients referred by the breast clinic, 6 of whom had biopsy-proven breast cancer. The CDMAM tests showed that the FFDM results were “acceptable” but fell short of “achievable” which was attributed to the low dose used. The ABUS images had good depth penetration (80 mm) and adequate axial resolution (0.5 mm) but the lateral resolution of 2 mm was judged to be too coarse. In a 42-year old volunteer with extremely dense breast tissue, the ABUS modality detected a lesion (a benign cyst) that was mammographically occult in the FFDM image. For a 73-year old patient with fatty breasts, a malignant lesion was successfully detected and co-registered in the FFDM and ABUS images. On average, each woman spent less than 11 minutes in the acquisition room. While there is room for improvement in the quality of both the FFDM and ABUS images, Aceso has demonstrated its ability to acquire clinically meaningful images for a range of women with varying breast densities and therefore has potential as a screening device.