Frequency domain near-infrared Spectroscopy of the uterine cervix during cervical ripening
Frequency domain near-infrared Spectroscopy of the uterine cervix during cervical ripening
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DOI：
10.1002/lsm.20542
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发表时间：
2007-09-01
影响因子：
2.4
通讯作者：
Hornung, Rene
中科院分区：
文献类型：
--
作者：
Banos, Ana;Wolf, Martin;Hornung, Rene
目的：早产是一种常见的产科并发症。宫颈成熟预测早产的临床评价在观察者间和观察者内有很大的差异。我们使用频域近红外光谱（FD-NIRS）来非侵入性地研究光学性质的变化（即，方法：对10名计划流产的志愿者进行了检查。在使用局部米索前列醇诱导宫颈成熟之前和之后，测量子宫颈的光学特性并计算生理参数。使用t检验计算氧合血红蛋白和脱氧血红蛋白、总血红蛋白、氧饱和度和水分的平均相对变化、平均值的标准误以及统计学显著性。通过指数拟合计算散射的波长依赖性降低（散射功率），并用Wilcoxon检验进行检验。氧合血红蛋白下降22 6%（P <0. 05），脱氧血红蛋白下降16 ± 11%，增加36 ± 8%（P < 0. 05）。005)水含量。结论：FD-NIRS是一种很有前途的检测宫颈血红蛋白和水分浓度变化的诊断工具。严重的组织水肿，可能是由于子宫内膜炎引起的炎症过程，似乎对宫颈成熟很重要。总血红蛋白的减少可能是组织含水量增加导致血管之间的距离急剧增加的结果。我们提出这项技术来评估宫颈成熟，并最终预测早产。
Objective: Preterm labor is a common obstetric complication. Clinical evaluation of cervical ripening to predict preterm labor has a substantial inter- and intraobserver variability. We used frequency domain near-infrared spectroscopy (FD-NIRS) to non-invasively investigate the changes of the optical properties (i.e., absorption and scattering of light) in the uterine cervix during drug-induced cervical ripening.Methods: Ten volunteers scheduled for abortion were examined. Optical properties of the uterine cervix were measured and physiological parameters were calculated prior to and after induction of cervical ripening using topical misoprostol. Mean relative changes, standard error of the mean as well as statistical significance using the t-test were calculated for oxy- and deoxyhemoglobin, total hemoglobin, oxygen-saturation, and water. The wavelength-dependent decrease of scattering (scatter power) was calculated by an exponential fit and tested with the Wilcoxon test.Results: Misoprostol induced a decrease in total hemoglobin of 21 +/- 6% (P < 0. 05), a decrease in oxyhemoglobin of 22 6% (P < 0.05), a decrease in deoxyhemoglobin of 16 +/- 11% and an increase of 36 +/- 8% (P < 0. 005) in water content. The scatter power was significantly lower (P < 0.05) after cervical ripening.Conclusion: Our results show that FD-NIRS is a promising diagnostic tool to detect changes in cervical concentrations of hemoglobin and water. A severe tissue edema, probably due to a hormone-induced inflammatory process, seems to be important for cervical ripening. The reduction in total hemoglobin is likely to be a consequence of the increased water content of the tissue resulting in a dramatic increase of the distance between vessels. We propose this technology to assess the cervical ripening and eventually to predict preterm labor.