What's eating you? An update on Giardia, the microbiome and the immune response.
What's eating you? An update on Giardia, the microbiome and the immune response.
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DOI：
10.1016/j.mib.2020.09.006
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发表时间：
2020-12
影响因子：
5.4
通讯作者：
Miskovsky E
中科院分区：
文献类型：
--
作者：
Singer SM;Angelova VV;DeLeon H;Miskovsky E
自从显微镜发明以来，人们就在人类粪便中发现了贾第鞭毛虫。然而，直到20世纪50年代人类实验性感染导致疟疾，它才被认为是一种病原体。我们现在知道，这种原生动物能够引起吸收不良性腹泻，这种寄生虫是幼儿发育迟缓的主要原因。然而，这种寄生虫的大多数感染并不伴有明显的腹泻，一些研究表明，它实际上对中度至重度腹泻有保护作用。因此，在贾第虫感染的临床结果中观察到的广泛变化的机制引起了极大的兴趣。本文将重点介绍寄生虫，宿主微生物组和免疫反应之间的相互作用的最新工作，以促进这种变化。
Giardia intestinalis has been observed in human stools since the invention of the microscope. However, it was not recognized as a pathogen until experimental infections in humans in the 1950s resulted in diarrheal illness. We now know that this protozoan is capable of inducing a malabsorptive diarrhea and that the parasite is a major contributor to stunting in young children. However, the majority of infections with this parasite are not accompanied by overt diarrhea and several studies indicate that it actually has a protective effect against moderate-severe diarrhea. There is therefore significant interest in the mechanisms responsible for the wide variation observed in the clinical outcomes of infection with Giardia. This review will highlight recent work on the interactions among the parasite, the host microbiome and the immune response as contributing to this variation.
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DOI：
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发表时间：
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期刊：
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影响因子：
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