Aiding the discovery of new treatments for dementia by uncovering unknown benefits of existing medications
Aiding the discovery of new treatments for dementia by uncovering unknown benefits of existing medications
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DOI：
10.1016/j.trci.2019.07.012
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发表时间：
2019-01-01
影响因子：
4.8
通讯作者：
Seabrook, Guy R.
中科院分区：
文献类型：
--
作者：
Kern, David M.;Cepeda, M. Soledad;Seabrook, Guy R.
目前，人们迫切需要改善疾病的治疗方法来治疗和预防痴呆症，包括阿尔茨海默病。真实世界的观察信息和新的分析技术，分析大量的数据的可用性可以提供一个路径，以帮助药物discovery.MethodsUsing一个自我控制的研究设计，我们研究了2181药物和痴呆症的发病率之间的关联在四个美国保险索赔数据库。在>= 2个数据库中检查了与痴呆症风险降低>= 50%相关的药物。结果分析中共纳入了117，015，066人。17种药物符合我们的阈值标准，对痴呆症的潜在保护作用，分为五类：儿茶酚胺调节剂，抗惊厥药，抗生素/抗病毒药，抗凝剂，和一个杂项group.DiscussionThe生物学途径的药物在此分析中确定可能是进一步研究的目标，并可能有助于发现新的治疗方法来治疗痴呆症。这些数据显示了相关性而非因果关系。
IntroductionThere is a significant need for disease-modifying therapies to treat and prevent dementia, including Alzheimer's disease. Availability of real-world observational information and new analytic techniques to analyze large volumes of data can provide a path to aid drug discovery.MethodsUsing a self-controlled study design, we examined the association between 2181 medications and incidence of dementia across four US insurance claims databases. Medications associated with >= 50% reduction in risk of dementia in >= 2 databases were examined.ResultsA total of 117,015,066 individuals were included in the analysis. Seventeen medications met our threshold criteria for a potential protective effect on dementia and fell into five classes: catecholamine modulators, anticonvulsants, antibiotics/antivirals, anticoagulants, and a miscellaneous group.DiscussionThe biological pathways of the medications identified in this analysis may be targets for further research and may aid in discovering novel therapeutic approaches to treat dementia. These data show association not causality.