Prostaglandins and renal function.
Prostaglandins and renal function.
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前列腺素和肾功能。
DOI：
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发表时间：
1978
期刊：
影响因子：
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通讯作者：
Norberte A. Terragno
中科院分区：
文献类型：
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作者：
J. Mcgiff;D. A. Terragno;Norberte A. Terragno
摘要前列腺素通过减弱肾素-血管紧张素系统的肾脏作用来调节血管活性激素的作用，并促进和介导激肽释放酶-激肽系统的某些作用。前列腺素机制参与调节肾素和促红细胞生成素的释放。当肾功能受损时，通过主要前列腺素组分的撤回维持肾脏的循环，其导致显著的血液动力学效应，特别是减少流向内皮质和髓质的血流。
Abstract Prostaglandins modulate the effects of vasoactive hormones by attenuating the renal actions of the renin-angiotensin system and contributing to and, perhaps, mediating some of those of the kallikrein-kinin system. A prostaglandin mechanism participates in the regulation of renin and erythropoietin release. When renal function is compromised, the circulation to the kidney is sustained by a major prostaglandin component withdrawal of which results in significant hemodynamic effects, particularly reduction of blood flow to the inner cortex and medulla.