Antinociception after microinjection of neurotensin into the central amygdaloid nucleus of the rat.
Antinociception after microinjection of neurotensin into the central amygdaloid nucleus of the rat.
复制标题
将神经降压素显微注射到大鼠中央杏仁核后的镇痛作用。
DOI：
10.1016/0006-8993(82)90251-7
复制
发表时间：
1982
期刊：
影响因子：
2.9
通讯作者：
PrangeJr,AJ
中科院分区：
文献类型：
--
作者：
Kalivas,PW;Gau,BA;Nemeroff,CB;PrangeJr,AJ
神经紧张素（NT）是一种内源性肽，被认为在中枢神经系统中作为一种神经递质起作用。在多种镇痛试验中，向啮齿动物脑室系统注射NT可产生抗痛觉。在热板实验中，将NT直接显微注射到杏仁核中央核（AC）可显著提高大鼠的伤害感受阈值，而将NT注射到杏仁核附近的组织一般无效。ed50剂量为2.4 μg NT时，ac内注射NT后的抗伤性明显低于侧脑室注射NT时的ed50剂量（93.2 μg NT）。损伤的终纹完全消除了AC内给药NT的抗痛觉作用，表明终纹内的AC传出或传入纤维是观察到的痛觉阈值升高所必需的。
Neurotensin (NT) is an endogenous peptide which has been hypothesized to function in the central nervous systems as a neurotransmitter. Injection of NT into the cerebral ventricular system of rodents produces antinociception in a variety of analgesia tests. In the hot plate test, direct microinjection of NT into the central nucleus of the amygdala (AC) produced a significant increase in the nociceptive threshold of the rat, while injections into tissue adjacent to the AC were generally ineffective. Antinociception following intra-AC injection of NT occurred at an ED50dose of 2.4 μg NT, and was significantly lower than the ED50dose observed when NT was given into the lateral ventricles (93.2 μg NT). Lesions of the stria terminalis totally abolished the antinociceptive effect of intra-AC administration of NT, indicating that AC efferent or afferent fibers within the stria terminalis are necessary for the observed increase in nociceptive threshold.