Protection of mice from infection with Streptococcus pneumoniae by anti-phosphocholine antibody.
Protection of mice from infection with Streptococcus pneumoniae by anti-phosphocholine antibody.
复制标题
抗磷酸胆碱抗体保护小鼠免受肺炎链球菌感染。
DOI：
10.1128/iai.36.1.184-188.1982
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发表时间：
1982
影响因子：
3.1
通讯作者：
Briles,DE
中科院分区：
文献类型：
--
作者：
Yother,J;Forman,C;Gray,BM;Briles,DE
抗磷酸胆碱（PC）抗体介导的对许多肺炎链球菌菌株的保护，杂交瘤抗PC抗体保护小鼠免受1型和3型肺炎链球菌的致命感染。肺炎。1、3、5、6A和19F S型带电。肺炎克雷伯氏菌具有相似量的可接近抗体的表面PC。此外，发现表达CBA/N株的X连锁免疫缺陷（xid）的小鼠对S. pneumoniae 3型、6A型和19F型的小鼠的免疫功能比免疫正常小鼠的免疫功能更强。这些结果的唯一例外是5型菌株，它对xid和正常小鼠都具有高毒性。此外，我们不能通过使用抗PC抗体来保护小鼠免受5型菌株的感染。
Anti-phosphocholine (PC) antibody mediated protection against many strains of Streptococcus pneumoniae, and hybridoma anti-PC antibodies protected mice from fatal infections with types 1 and 3 S. pneumoniae. Live types 1, 3, 5, 6A, and 19F S. pneumoniae had similar amounts of surface PC accessible to antibody. Furthermore, mice expressing the X-linked immunodeficiency (xid) of the CBA/N strain were found to be more susceptible to infection with S. pneumoniae of types 3, 6A, and 19F than were immunologically normal mice. The only exception to these results was with the type 5 strain, which was highly virulent for both xid and normal mice. In addition, we were unable to protect mice against infection with the type 5 strain by using anti-PC antibody.