Life and death of lymphocytes: a role in immunesenescence.
Life and death of lymphocytes: a role in immunesenescence.
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DOI：
10.1186/1742-4933-2-12
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发表时间：
2005-08-23
影响因子：
7.9
通讯作者：
Gollapudi, Sastry
中科院分区：
文献类型：
--
作者：
Gupta, Sudhir;Su, Houfen;Bi, Ruifen;Agrawal, Sudhanshu;Gollapudi, Sastry
人类衰老与免疫功能的进行性下降，感染频率增加有关。在免疫功能中，衰老期间T细胞功能的下降占主导地位。本文将讨论细胞凋亡的两条主要途径，即死亡受体途径和线粒体途径，以及它们在人类衰老过程中T和B淋巴细胞中的变化，特别强调幼稚和不同记忆亚群的CD8+ T细胞。我们还将讨论淋巴细胞凋亡在免疫衰老中的可能作用。
Human aging is associated with progressive decline in immune functions, increased frequency of infections. Among immune functions, a decline in T cell functions during aging predominates. In this review, we will discuss the molecular signaling in two major pathways of apoptosis, namely death receptor pathway and mitochondrial pathway, and their alterations in both T and B lymphocytes in human aging with a special emphasis on naïve and different memory subsets of CD8+ T cells. We will also discuss a possible role of lymphocyte apoptosis in immune senescence.