Tenascin-W: Discovery, Evolution, and Future Prospects.
Tenascin-W: Discovery, Evolution, and Future Prospects.
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DOI：
10.3389/fimmu.2020.623305
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发表时间：
2020
影响因子：
7.3
通讯作者：
Tucker RP
中科院分区：
文献类型：
--
作者：
Degen M;Scherberich A;Tucker RP
在硬骨鱼和四足动物中发现的四种腱生蛋白中，腱生蛋白-W是最不了解的。它首先在斑马鱼中被发现，后来在小鼠中被错误地命名为tenascin-N。生腱蛋白-W主要在发育和成熟骨中、在干细胞小生境的子集中以及在许多实体瘤的基质中表达。系统发育研究表明，它是最近进化的腱生蛋白，首先出现在硬骨鱼中。它在骨中的表达及其进化出现的时间应该指导未来的研究，以其在骨形成，干细胞壁龛，以及癌症的治疗和检测中的作用。
Of the four tenascins found in bony fish and tetrapods, tenascin-W is the least understood. It was first discovered in the zebrafish and later in mouse, where it was mistakenly named tenascin-N. Tenascin-W is expressed primarily in developing and mature bone, in a subset of stem cell niches, and in the stroma of many solid tumors. Phylogenetic studies show that it is the most recent tenascin to evolve, appearing first in bony fishes. Its expression in bone and the timing of its evolutionary appearance should direct future studies to its role in bone formation, in stem cell niches, and in the treatment and detection of cancer.