Depressive patients are more impulsive and inconsistent in intertemporal choice behavior for monetary gain and loss than healthy subjects--an analysis based on Tsallis' statistics.
Depressive patients are more impulsive and inconsistent in intertemporal choice behavior for monetary gain and loss than healthy subjects--an analysis based on Tsallis' statistics.
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发表时间：
2008-06
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通讯作者：
Taiki Takahashi;Hidemi Oono;Takeshi Inoue;S. Boku;Yuki Kako;Yuji Kitaichi;I. Kusumi;T. Masui
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作者：
Taiki Takahashi;Hidemi Oono;Takeshi Inoue;S. Boku;Yuki Kako;Yuji Kitaichi;I. Kusumi;T. Masui
抑郁症与奖赏和惩罚的神经处理受损有关。然而，到目前为止，很少有人知道抑郁症和跨期选择（延迟折扣）的收益和损失之间的关系。这项研究对于跨期选择的神经经济学的进展具有潜在的重要意义，因为抑郁症与大脑中多巴胺能活动的减少有关。设计和设置我们比较了抑郁症患者和健康对照组之间的冲动性和不一致性的跨期选择的金钱收益和损失。方法采用获得和损失的延迟折扣任务对抑郁症患者和健康对照者进行测试。然后，我们量化的冲动性和不一致的延迟折扣与参数的q指数折扣函数的基础上Tsallis的统计。结果抑郁症患者在获得和损失的跨期选择行为中表现出更强的冲动性和时间不一致性。主要研究结果抑郁症患者在时间折扣方面更不合理。结论：q指数折扣函数对抑郁症患者决策障碍的评估是有效的。此外，生物物理机制改变的跨期选择抑郁症患者进行了讨论，受损的神经系统。
OBJECTIVES Depression has been associated with impaired neural processing of reward and punishment. However, to date, little is known regarding the relationship between depression and intertemporal choice (delay discounting) for gain and loss. This examination is potentially important for advances in neuroeconomics of intertemporal choice, because depression is associated with reduced serotonergic activities in the brain. DESIGN AND SETTING We compared impulsivity and inconsistency in intertemporal choice for monetary gain and loss between depressive patients and healthy control subjects. METHODS We conducted delay discounting tasks for gain and loss in depressed and healthy control subjects. We then quantified impulsivity and inconsistency in the delay discounting with parameters in the q-exponential discount function based on Tsallis' statistics. RESULTS We observed that depressive patients were more impulsive and time-inconsistent in intertemporal choice action for gain and loss, in comparison to healthy controls. MAIN FINDINGS Depressed patients were more irrational in temporal discounting. CONCLUSIONS The usefulness of the q-exponential discount function for assessing the impaired decision-making by depressive patients was demonstrated. Furthermore, biophysical mechanisms underlying the altered intertemporal choice by depressive patients are discussed in relation to impaired serotonergic neural systems.