Association between altered thyroid state and insulin resistance.
Association between altered thyroid state and insulin resistance.
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DOI：
10.4103/0976-500x.95517
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发表时间：
2012-04
影响因子：
0.2
通讯作者：
Shah JS
中科院分区：
文献类型：
--
作者：
Kapadia KB;Bhatt PA;Shah JS
确定甲状腺激素改变与胰岛素抵抗（IR）之间的关系。在印度艾哈迈达巴德的Care医学科学研究所，对8例无既往病史的甲状腺功能正常（EU）、甲状腺功能低下（HO）和甲状腺功能亢进（HR）患者进行了横断面研究，分析了空腹血液样本的促甲状腺激素（TSH）、血脂、胰岛素和葡萄糖。计算稳态模型评估（HOMA）来评估IR。HR组和HO组HOMA值显著高于EU组（P < 0.05）。与EU组相比，HR组和HO组胰岛素水平显著升高（P < 0.05）。与EU和HR组相比，HO组的胆固醇、甘油三酯（TG）和低密度脂蛋白（LDL）显著升高（P < 0.05），高密度脂蛋白（HDL）水平降低。HOMA和胰岛素与HO组TSH呈正相关，与HR组TSH呈负相关。由于胰岛素分泌和脂质水平的改变等多种机制，甲状腺疾病（包括低和高）与IR相关。在HO和HR患者中IR具有可比性。虽然HO和HR构成IR状态，但需要更多的研究来阐明其潜在的致病机制。因此，甲状腺状态的改变可导致IR导致血糖相关疾病，如糖尿病血脂异常。
To determine the association between altered thyroid hormones and insulin resistance (IR). Eight euthyroid (EU), eight hypothyroid (HO), and eight hyperthyroid (HR) patients with no past medical history were studied in this cross-sectional study at the Care Institute of Medical Sciences, Ahmedabad, India, The fasting blood sample were analyzed for thyroid stimulating hormone (TSH), lipid profile, insulin, and glucose. Homeostatic model assessment (HOMA) was calculated for assessing IR. HOMA values were significantly higher in HR and HO groups as compared to the EU group (P < 0.05). Insulin levels were also found to be significantly increased in HR and HO groups as compared to the EU group (P < 0.05). Cholesterol, triglycerides (TG), and low density lipoprotein (LDL) were significantly raised in HO as compared to EU and HR groups (P < 0.05) whereas high density lipoprotein levels (HDL) were lower. HOMA and insulin were found to be positively correlated with TSH in HO and negatively in HR. Thyroid disorder, including both hypo- and hyper have been associated with IR due to various mechanisms such as altered insulin secretion and lipid levels. IR was comparable in patients with both HO and HR. Although HO and HR constitute an IR state, more studies need to be done in order to clarify the underlying pathogenic mechanism. Thus, an altered thyroid state can lead to IR leading to glucose-related disorder such as diabetes dyslipidemia.