Genetic risk and likelihood of prostate cancer detection on first biopsy by ancestry.
Genetic risk and likelihood of prostate cancer detection on first biopsy by ancestry.
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首次活检时检测出前列腺癌的遗传风险和可能性。
DOI：
10.1093/jnci/djae002
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发表时间：
2024
期刊：
影响因子：
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通讯作者：
Lynch,JulieA
中科院分区：
文献类型：
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作者：
Lee,KyungMin;Nelson,Tyler;Bryant,Alex;Teerlink,Craig;Gulati,Roman;Pagadala,Meghana;Tcheandjieu,Catherine;Pridgen,KathrynM;DuVall,ScottL;Yamoah,Kosj;Vassy,JasonL;Seibert,TylerM;Hauger,Richard;Rose,BrentS;Lynch,JulieA
尽管不同血统群体的前列腺癌风险存在差异，但不同血统群体中前列腺癌遗传风险评分（GRS）对活检阳性预测的相对表现尚不清楚。这项横断面回顾性分析使用双边测试检查了多基因风险评分 (PHS290) 与男性退伍军人首次活检时诊断前列腺癌的风险之间的关联。我们的分析包括 36 717 名退伍军人（10 297 名非洲血统）。未经调整的首次前列腺活检阳性率随着遗传风险的增加而增加（低风险：34%，高风险：58%；P< .001）。在非洲血统的男性中，较高的遗传风险与首次活检时前列腺癌检出率的增加相关（比值比 = 2.18，95% 置信区间 = 1.93 至 2.47），但这种影响在欧洲血统的男性中更强（比值比 = 3.89，95% 置信区间 = 3.62 至 4.18）。这些发现表明，将遗传风险纳入预测模型可以更好地个性化活检决策，尽管需要进一步研究以实现血统群体之间公平的遗传风险分层。
Despite differences in prostate cancer risk across ancestry groups, relative performance of prostate cancer genetic risks scores (GRS) for positive biopsy prediction in different ancestry groups is unknown. This cross-sectional retrospective analysis examines the association between a polygenic hazard score (PHS290) and risk of prostate cancer diagnosis upon first biopsy in male veterans using 2-sided tests. Our analysis included 36 717 veterans (10 297 of African ancestry). Unadjusted rates of positive first prostate biopsy increased with higher genetic risk (low risk: 34%, high risk: 58%;P< .001). Among men of African ancestry, higher genetic risk was associated with increased prostate cancer detection on first biopsy (odds ratio = 2.18, 95% confidence interval = 1.93 to 2.47), but the effect was stronger among men of European descent (odds ratio = 3.89, 95% confidence interval = 3.62 to 4.18). These findings suggest that incorporating genetic risk into prediction models could better personalize biopsy decisions, although further study is needed to achieve equitable genetic risk stratification among ancestry groups.