Energy balance in adrenalectomized ob/ob mice: effects of dietary starch and glucose.
Energy balance in adrenalectomized ob/ob mice: effects of dietary starch and glucose.
复制标题
肾上腺切除的 ob/ob 小鼠的能量平衡：膳食淀粉和葡萄糖的影响。
DOI：
10.1152/ajpregu.1988.255.1.r141
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Romsos,DR
中科院分区：
文献类型：
--
作者：
Warwick,BP;Romsos,DR
研究了不同类型碳水化合物对去肾上腺ob/ob小鼠能量平衡、脂肪酸合成和血浆胰岛素浓度的影响。肥胖(ob/ob)和瘦小鼠在4周龄时切除肾上腺，接受四种高碳水化合物粉末饲料中的一种，为期3周：原料、葡萄糖、淀粉或淀粉加小麦麸皮。肾上腺切除减少了ob/ob小鼠的能量摄入量，与饮食类型无关，而能量效率、肝脏和白色脂肪组织中体内脂肪酸合成的速率以及血浆胰岛素浓度在所有肾上腺切除的ob/ob小鼠中都大幅降低到接近于值，但那些喂食葡萄糖的小鼠除外。切除肾上腺使肥胖/肥胖小鼠的能量平衡正常化的能力取决于其他因素，而不是仅靠降低糖皮质激素的循环浓度。饮食构成是一个关键因素，含有单糖(葡萄糖)的半纯饮食与含有复杂碳水化合物(淀粉)的半纯饮食之间存在显著差异，不含额外的膳食纤维(麦麸皮)。
Effects of different carbohydrate types on energy balance, fatty acid synthesis, and plasma insulin concentrations in adrenalectomized ob/ob mice were investigated. Obese (ob/ob) and lean mice adrenalectomized at 4 wk of age received one of four high-carbohydrate powdered diets for 3 wk: stock, glucose, starch, or starch plus wheat bran. Adrenalectomy reduced energy intake of ob/ob mice equally independent of diet type, whereas energetic efficiency, in vivo rates of fatty acid synthesis in liver and white adipose tissue, and plasma insulin concentrations were substantially reduced to approach values in lean mice in all adrenalectomized ob/ob mice except those fed glucose. The ability of adrenalectomy to normalize energy balance in ob/ob mice depends on factors other than the reduced circulating concentration of glucocorticoids alone. Diet composition is a crucial factor, and striking differences exist between semipurified diets containing a simple sugar (glucose) and those containing a complex carbohydrate (starch), with no additional effect of dietary fiber (wheat bran).