Significance of the Ki-67 proliferation index in the assessment of the therapeutic response to cisplatin-based chemotherapy in patients with advanced cervical cancer
Significance of the Ki-67 proliferation index in the assessment of the therapeutic response to cisplatin-based chemotherapy in patients with advanced cervical cancer
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DOI：
10.26355/eurrev_201808_15710
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发表时间：
2018-08-01
影响因子：
3.3
通讯作者：
Zivadinovic, A.
中科院分区：
文献类型：
--
作者：
Krtinic, D.;Zivadinovic, R.;Zivadinovic, A.
目的：本研究的目的是检查晚期宫颈癌对 Ki-67 增殖指数（Ki-67 PI）依赖性顺铂化疗的治疗反应，并确定 KI-67 PI 参考值，该值有望为宫颈癌对顺铂化疗提供满意的治疗反应。 患者和方法：这项前瞻性研究纳入了塞尔维亚尼斯临床中心肿瘤诊所治疗的 59 名宫颈癌患者。根据获得的Ki-67 PI值，将患者分为三组，所有患者均接受相同的细胞抑制剂顺铂治疗。从第一次化疗起随访一年后，评估化疗的治疗反应是否存在疾病进展以及无进展生存期。 结果：通过 Kaplan-Meier 生存分析，生存率随着 Ki-67 PI 的增加而增加，这意味着 Ki-67 PI < 40% 的患者组的生存率与其他两组患者相比在统计学上显着缩短 (p=0.010)。 Mann-Whitney 检验证实，根据 Ki-67 PI 形成的患者组的生存率在统计学上显着增加（p = 40%）。
OBJECTIVE: The purposes of this study were to examine the therapeutic response of advanced cervical cancerto Ki-67 proliferative index (Ki-67 PI) dependent cisplatin chemotherapy, and to determine KI-67 PI referential value that is expected to provides satisfactory therapeutic response of cervical cancer to cisplatin chemotherapy.PATIENTS AND METHODS: This prospective study enrolled 59 patients treated for cervical cancer at Clinic for Oncology, Clinical Center Nis, Serbia. According to the obtained Ki-67 PI values, patients were divided into three groups, and all the patients received the same cytostatic, cisplatin. Therapeutic response to chemotherapy was evaluated in relation to disease progression presence or absence and progression-free survival after a year follow-up since the first chemotherapy.RESULTS: Survival rate increases with an increase of Ki-67 PI by Kaplan-Meier survival analysis, meaning that survival rate is statistically significantly shorter in the group of patients with Ki-67 PI < 40% in comparison to patients from other two groups (p=0.010). Mann-Whitney test confirmed a statistically significant increase in survival rate among the groups of patients formed according to Ki-67 PI (p= 40%).