Synthesis and Bioactivities of Novel Pyrazole and Triazole Derivatives Containing 5-Phenyl-2-Furan
Synthesis and Bioactivities of Novel Pyrazole and Triazole Derivatives Containing 5-Phenyl-2-Furan
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DOI：
10.1111/j.1747-0285.2011.01266.x
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发表时间：
2012-01-01
影响因子：
3
通讯作者：
Yang, Xin-Ling
中科院分区：
文献类型：
--
作者：
Cui, Zi-Ning;Shi, Yan-Xia;Yang, Xin-Ling
设计并合成了一系列新型含5-苯基-2-呋喃官能团的吡唑和三唑衍生物。它们的毒性使用计算机分析进行预测，并证明毒性较低。抗肿瘤实验结果表明，含1，3，4-三唑的化合物（系列II）的抗肿瘤活性高于含吡唑的衍生物（系列I）。其中，IIa和IIg对Bel-7402的活性远高于阿霉素。室内杀菌试验表明，大部分标题化合物对辣椒疫霉菌表现出较强的选择性。
A series of novel pyrazole and triazole derivatives containing 5-phenyl-2-furan functionality were designed and synthesized. Their toxicities were predicted using in silico assays and proven to be less toxic. The antitumor results showed that the activity of compounds containing 1,3,4-triazole (series II) was higher than that of pyrazole-attached derivatives (series I). Among them, IIa and IIg showed much higher activity against Bel-7402 than doxorubicin. The fungicidal tests showed that most title compounds II exhibited great selectivity against Phytophthora capsici in vivo.