Cu-catalyzed one-pot synthesis of fused oxazepinone derivatives via sp(2) C-H and O-H cross-dehydrogenative coupling
Cu-catalyzed one-pot synthesis of fused oxazepinone derivatives via sp(2) C-H and O-H cross-dehydrogenative coupling
复制标题
铜催化 sp(2) C-H 和 O-H 交叉脱氢偶联一锅法合成稠合氧氮杂酮衍生物
DOI：
10.1039/c6qo00040a
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发表时间：
2016
影响因子：
5.4
通讯作者：
Ma Chen
中科院分区：
文献类型：
--
作者：
Zhang Zeyuan;Dai Zhen;Ma Xinkun;Liu Yihan;Ma Xiaojun;Li Wanli;Ma Chen
开发了一种高效的铜催化级联反应方案，用于通过 sp2 C-H 和 O-H 交叉脱氢偶联合成稠合氧氮杂酮衍生物。这种模块化聚合方法使用了一种现成的催化剂 Cu2O。该合成涉及不寻常的 Smiles 重排反应。对各种反应参数进行了评估和优化，并以良好至优异的收率获得了目标化合物。
An efficient Cu-catalyzed cascade reaction protocol was developed for the synthesis of fused oxazepinone derivatives via sp2 C–H and O–H cross-dehydrogenative coupling. A readily available catalyst, Cu2O, was used in this modular and convergent approach. An unusual Smiles rearrangement reaction was involved in this synthesis. Various reaction parameters were evaluated and optimized, and the target compounds were obtained in good-to-excellent yields.