rac-2-[(2-Chloro-phen-yl)(4-chloro-phen-yl)meth-yl]-1,3-dioxolane.
rac-2-[(2-Chloro-phen-yl)(4-chloro-phen-yl)meth-yl]-1,3-dioxolane.
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rac-2-[(2-氯苯基)(4-氯苯基)甲基]-1,3-二氧戊环。
DOI：
10.1107/s1600536812023781
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
deOliveira,BrásH
中科院分区：
文献类型：
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作者：
Maluf,DanielaF;DosSantos,SailerS;Gatto,ClaudiaC;deOliveira,BrásH
标题化合物C16 H14 Cl 2 O2是一种手性米托烷衍生物，含有一个二氧戊环，从甲醇中结晶为外消旋混合物。在碱性介质中，以米托坦和乙二醇为原料，用硫酸中和，乙酸乙酯萃取，可得到高产率的产品。分子结构由分子内的C-H-O氢键稳定.芳环间的二面角为80.1（2）°。 二氧戊环采用褶皱的信封构象与O原子作为皮瓣。
The title compound, C16H14Cl2O2, is a chiral mitotane derivative that contains a dioxolane ring and crystallizes from methanol as a racemic mixture. It was obtained in high yield from mitotane and ethyleneglycol in alkaline medium, followed by neutralization with sulfuric acid and extraction with ethyl acetate. The molecular structure is stabilized by an intramolecular C— H⋯ O hydrogen bond. The dihedral angle between the aromatic rings is 80.1 (2)°. The dioxolane ring adopts a puckered envelope conformation with an O atom as the flap.