Real-time concentration monitoring in microfluidic system via plasmonic nanocrescent arrays.
Real-time concentration monitoring in microfluidic system via plasmonic nanocrescent arrays.
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DOI：
10.1016/j.bios.2015.09.054
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发表时间：
2016-03
影响因子：
12.6
通讯作者：
Bingpu Zhou;X. Xiao;Ting Liu;Yibo Gao;Yingzhou Huang;W. Wen
中科院分区：
文献类型：
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作者：
Bingpu Zhou;X. Xiao;Ting Liu;Yibo Gao;Yingzhou Huang;W. Wen
本文报道了一种基于电子束光刻法制备的纳米结构的局域表面等离子体共振的片上生物/化学传感器。根据时域有限差分模型的模拟结果，不同尺寸特征的纳米晶体阵列具有可控的等离子体特性。当两个相对的新月体具有约43.3 nm的间隙时，所制备的样品的最高折射率灵敏度达到约699.2 nm/RIU，品质因数为约3.1。这种获得的等离子体传感器进一步集成到微流体系统中，该微流体系统可以通过调节两个注入微流之间的流速比来简单地控制特定分析物浓度。我们的方法已经成功地证明了能力的nanocomposites图案作为芯片上的等离子体生物/化学传感器，用于实时监测动态浓度的微通道。
In this work, on-chip bio/chemical sensor was reported based on localized surface plasmon resonance of nanocrescent patterns fabricated via electron beam lithography. The nanocrescent arrays with different dimensional features exhibited controllable plasmonic properties in accordance with the simulation results based on the finite-difference time-domain model. The highest refractive index sensitivity of the fabricated samples was achieved to be ~699.2 nm/RIU with a figure of merit of ~3.1 when the two opposite crescents own a gap of ~43.3 nm. Such obtained plasmonic sensor was further integrated into the microfluidic system which can simply control the specific analyte concentrations via tuning the flow rate ratios between two injecting microstreams. Our method has successfully demonstrated the capability of the nanocrescent patterns as on-chip plasmonic bio/chemical sensor for real-time monitoring of dynamic concentrations in the microchannel.