High pain frequency in narcolepsy with cataplexy
High pain frequency in narcolepsy with cataplexy
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DOI：
10.1016/j.sleep.2011.01.010
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发表时间：
2011-06-01
期刊：
影响因子：
4.8
通讯作者：
Garcia-Borreguero, Diego
中科院分区：
文献类型：
--
作者：
Dauvilliers, Yves;Bayard, Sophie;Garcia-Borreguero, Diego
背景：发作性睡病伴卡他汀（NC）是由下丘脑泌素神经元缺失引起的。最近的研究强调了hypocretins在调节伤害性传递中的作用。本多中心病例对照研究的目的是观察NC中疼痛的频率，并研究疼痛对发作性睡病症状和生活质量（QoL）的决定因素和影响。67例NC成人患者及其医生、伴侣/朋友以及性别和年龄匹配的正常对照组接受了面对面访谈，并完成了关于疼痛存在和频率的问卷调查，结果：三分之一（32.8%）的NC患者至少每月经历一次疼痛，其频率和影响显著高于对照组（17.9%），且与患者的发作性睡病药物无关。患者和伴侣/朋友之间的疼痛报告匹配良好，但患者和医生之间存在显著差异，医生显著低估了其频率和影响。慢性疼痛的位置在受试者中不同，NC和对照组之间存在差异。我们指出，睡眠量和抑郁症的疼痛的决定因素，慢性疼痛有显着的影响，睡眠量，抑郁症和生活质量NC。结论：我们报告，第一次，证据表明，慢性疼痛是显着更常见和禁用NC相比，一般人群。研究结果呼吁提高注意NC的后续疼痛的评估和治疗。(C)2011爱思唯尔有限公司版权所有。
Background: Narcolepsy with cataplexy (NC) is caused by the loss of hypocretin neurons. Recent studies highlighted the roles for hypocretins in the modulation of nociceptive transmission. The aims of the present multicenter case-control study were to look at the frequency of pain in NC and to study the determinants and impact of pain on narcolepsy symptoms and quality of life (QoL).Methods: Sixty-seven adult patients with NC, together with their physician, partner/friend, and sex- and age-matched normal controls underwent a face-to-face interview and completed questionnaires on the presence and frequency of pain, narcolepsy symptoms and QoL (Short-Form 36-item score, Functional Outcomes of Sleep Questionnaire, Medical Outcomes Study, Fatigue Severity Scale, and Beck Depression Inventory).Results: One-third (32.8%) of NC patients experienced pain at least monthly, with a significantly higher frequency and impact than controls (17.9%) and independent of the patients' narcolepsy medication. The reporting of pain was well matched between patients and partners/friends but significant differences were observed between patients and physicians, with physicians significantly underestimating its frequency and impact. The location of chronic pain varies within subjects with differences between NC and controls. We pinpointed that sleep quantity and depression were determinants for pain, and chronic pain had significant impact on sleep quantity, depression and QoL in NC.Conclusion: We report, for the first time, evidence that chronic pain is significantly more common and disabling in NC compared to the general population. The findings call for improved attention to assessment and treatment of pain in the follow-up of NC. (C) 2011 Elsevier B.V. All rights reserved.