The Association of Cigarette Smoking With High-Frequency Heart Rate Variability: An Ecological Momentary Assessment Study.
The Association of Cigarette Smoking With High-Frequency Heart Rate Variability: An Ecological Momentary Assessment Study.
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DOI：
10.1097/psy.0000000000000507
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发表时间：
2017
影响因子：
3.3
通讯作者：
Sloan RP
中科院分区：
文献类型：
--
作者：
Bodin F;McIntyre KM;Schwartz JE;McKinley PS;Cardetti C;Shapiro PA;Gorenstein E;Sloan RP
来自实验室和观察性研究的证据表明，急性和慢性吸烟会导致高频心率变异性（HF-HRV）降低，这是一种衡量心脏迷走神经调节的指标。我们利用生态瞬时评估（EMA）来研究吸烟对并发HF-HRV的影响，在一项测量敌意减少的影响的试验中，并比较了吸烟者和非吸烟者的24小时HF-HRV。随机化前，从149名健康、敌意水平高的个体（20-45岁，BMI ≤ 32 kg/m2）中收集动态ECG数据，并与吸烟和清醒时身体姿势的同时EMA评级配对。估计了一个多水平混合模型，将ln（HF-HRV）与吸烟状态（人与人之间的因素）和以人为中心的瞬时吸烟（人与人之间的因素，作为随机效应）相关联，调整瞬时身体位置，药物使用以及酒精和咖啡因的消耗。35名吸烟者和114名非吸烟者提供了EMA和HF-HRV数据。在吸烟者中，当参与者报告最近吸烟时，与没有吸烟时相比，ln HF-HRV降低了0.31 ms 2（p=0.04）。吸烟者的24小时HF-HRV（平均值= 5.24 ± SD = 0.14 ms 2）显著低于非吸烟者（5.63 ± 0.07 ms 2; p=0.01）。“在日常生活中，健康的，具有高敌意水平的吸烟者作为自己的对照，吸烟严重降低了HF-HRV。与非吸烟者相比，吸烟者的HF-HRV也降低。虽然受少数敌意水平高的个体样本的限制，但这些发现仍然提供了额外的证据，表明吸烟降低了心脏迷走神经调节，这可能是吸烟的众多病理生理学影响之一。
Evidence from both laboratory and observational studies suggests that acute and chronic smoking leads to reduced high frequency heart rate variability (HF-HRV), a measure of cardiac vagal regulation. We utilized ecological momentary assessment (EMA) to study the effect of smoking on concurrent HF-HRV in a trial measuring the effects of hostility reduction, and compared 24-hour HF-HRV in smokers and non-smokers. Ambulatory ECG data were collected pre-randomization from 149 healthy, individuals with high hostility levels (20–45 years, BMI ≤ 32 kg/m2) and paired with concurrent EMA ratings of smoking, and physical position during waking hours. A multilevel mixed model was estimated associating ln(HF-HRV) from smoking status (between-person factor) and person-centered momentary smoking (within-person factor, treated as a random effect), adjusting for momentary physical position, medication use, and consumption of alcohol and caffeine. 35 smokers and 114 non-smokers provided both EMA and HF-HRV data. Within smokers, ln HF-HRV was reduced by 0.31 ms2 (p=0.04) when participants reported having recently smoked cigarettes, compared to when they had not. The 24-hour HF-HRV was significantly lower in smokers (mean = 5.24 ± SD = 0.14 ms2) than non-smokers (5.63 ± 0.07 ms2; p=0.01)." In healthy, smokers with high hostility levels used as their own controls during daily living, smoking acutely reduced HF-HRV. HF-HRV was also reduced in smokers as compared to non-smokers. Although limited by a small sample of individuals with high hostility levels, these findings nonetheless provide additional evidence that cardiac vagal regulation is lowered by cigarette smoking, which may be one of the numerous pathophysiological effects of smoking.