MODEL OF LOCAL CONNECTIVITY PATTERNS IN CA3 AND CA1 AREAS OF THE HIPPOCAMPUS
MODEL OF LOCAL CONNECTIVITY PATTERNS IN CA3 AND CA1 AREAS OF THE HIPPOCAMPUS
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DOI：
10.1002/hipo.450040502
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发表时间：
1994-10-01
期刊：
影响因子：
3.5
通讯作者：
WHEAL, HV
中科院分区：
文献类型：
--
作者：
BERNARD, C;WHEAL, HV
在这项研究中，我们描述了一个连接年轻雄性大鼠海马CA3和CA1区域不同神经元的连接模型。模型中使用的参数的解剖和电生理值是从现有文献中选择的。每种类型的突触的特征是其在树突树上的空间位置，其重量，激活概率以及所涉及的嗜离子受体。我们已经证明，输入的收敛和发散程度高度依赖于神经元的类型及其空间位置。我们描述的连接的不同梯度从功能的角度支持板层假说，即使解剖模式似乎分散。对一类神经元的共同传入事件的比例的分析进一步证实了这一点。有人认为，在信息处理方面，电路通过建立优先处理信息的受限区域来创造局部一致性。这些发现的功能后果和局限性也进行了讨论。该模型是开发具有现实结构的海马体网络模型的第一步。(C) 1994 Wiley-Liss, Inc。
In this study we describe a model of connectivity linking the different neurons in the CA3 and CA1 areas of the young male rat hippocampus. The anatomical and electrophysiological values of the parameters used in the model were selected from the available literature. Each type of synapse was characterized by its spatial location on the dendritic tree, its weight, its probability of activation, and the ionotropic receptors involved. We have shown that the degree of convergence and divergence of inputs is highly dependent upon the type of neuron and its spatial location. The different gradients of connectivity we describe support the lamellar hypothesis from a functional point of view, even if the anatomical patterns seem diffuse. The analysis of the proportion of common afferents to a class of neurons further confirmed this point. It is suggested that the circuitry creates local coherence in terms of processing of information by establishing restricted areas where information is preferentially treated. The functional consequences and limitations of these findings are also discussed. This model is the first step in the development of a network model of the hippocampus with realistic architecture. (C) 1994 Wiley-Liss, Inc.