GLUTAMATE NEUROTOXICITY IN THE DEVELOPING RAT COCHLEA - PHYSIOLOGICAL AND MORPHOLOGICAL APPROACHES
GLUTAMATE NEUROTOXICITY IN THE DEVELOPING RAT COCHLEA - PHYSIOLOGICAL AND MORPHOLOGICAL APPROACHES
复制标题
DOI：
10.1016/0006-8993(91)90090-i
复制
发表时间：
1991-06-28
期刊：
影响因子：
2.9
通讯作者：
JENSEN, KF
中科院分区：
文献类型：
--
作者：
JANSSEN, R;SCHWEITZER, L;JENSEN, KF
研究外源性谷氨酸对大鼠耳蜗神经的毒性作用。谷氨酸处理的大鼠(每天4g/kg，出生后第2-9天)表现出电生理测量的高频阈值升高，通常与耳蜗基底部毛细胞的丢失有关。虽然Corti器官的表面准备没有显示毛细胞的丢失，但螺旋神经节的高频相关基础部分的神经元显著和选择性地减少。发育中的螺旋神经节细胞对谷氨酸的神经毒性的敏感性与谷氨酸或结构上的相关物质是耳蜗毛细胞传入突触的神经递质的假说一致。
The neurotoxic effects of exogenous glutamate were studied in the rate cochlea. Glutamate-treated rats (4 g/kg/day i.p., postnatal days 2-9) exhibited electrophysiologically-measured elevations in high frequency threshold usually associated with hair cell loss in the basal region of the cochlea. While surface preparations of the organ of Corti revealed no loss of hair cells, there was a dramatic and selective reduction of neurons in the basal, high frequency-related portion of the spiral ganglion. This sensitivity of developing spiral ganglion cells to the neurotoxicity of glutamate is consistent with the hypothesis that glutamate or a structurally related substance is a neurotransmitter at afferent synapses of cochlear hair cells.