Evidence for an enhancement of excitatory transmission in adult CNS by Wnt signaling pathway modulation
Evidence for an enhancement of excitatory transmission in adult CNS by Wnt signaling pathway modulation
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DOI：
10.1016/j.mcn.2007.03.004
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发表时间：
2007-08-01
影响因子：
3.5
通讯作者：
Munoz-Sanjuan, Ignacio
中科院分区：
文献类型：
--
作者：
Beaumont, Vahri;Thompson, Sally-Anne;Munoz-Sanjuan, Ignacio
Wnt信号转导在突触发生、神经发生和细胞命运特化中的作用已经得到很好的表征。相比之下，Wnt信号通路在突触可塑性和成人生理调节中的作用才刚刚开始阐明。在这里，我们已经确定了一系列新的Wnt通路小分子调节剂，并报告说，这些和其他小分子靶向Wnt通路急性增强兴奋性传输成人海马制剂。我们的研究结果与突触前和突触后作用部位一致，导致自发性和诱发性神经传递以不依赖于转录的方式发生。(c)2007爱思唯尔公司All rights reserved.
The role for Wnt signaling modulation during synaptogenesis, neurogenesis and cell fate specification have been well characterized. In contrast, the roles for Wnt signaling pathways in the regulation of synaptic plasticity and adult physiology are only starting to be elucidated. Here, we have identified a novel series of Wnt pathway small molecule modulators, and report that these and other small molecules targeting the Wnt pathway acutely enhance excitatory transmission in adult hippocampal preparations. Our findings are consistent with a pre- and postsynaptic site of action, leading to both increased spontaneous and evoked neurotransmission that occurs in a transcription-independent fashion. (c) 2007 Elsevier Inc. All rights reserved.